APR 15, 2017 6:26 PM PDT

Aspirin Therapy Not As Effective As Previously Thought

WRITTEN BY: Kara Marker

How effective is aspirin for treating peripheral vascular disease, really? A large-scale meta-analysis introduces the idea that aspirin could be not very effective at all, potentially even harmful. The new study calls for more experiments to make a definitive statement on the efficacy of aspirin for treating peripheral vascular disease (PVD) and other heart conditions.

PVD consists of blood vessel maladies outside of those in the heart and brain - arteries that carry blood to the limbs, stomach, and kidneys. Two forms of PVD determine a range of possible symptoms; functional PVD involves no physical damage to the blood vessels and is characterized by fluctuating muscle spasms, and organic PVD describes structural changes to blood vessels, causing inflammation and tissue damage. Overall PVD is accompanied by a reduction in blood flow, affecting more than eight million people in the United States.

Aspirin is a classic example of a common drug used to treat heart and blood vessel conditions, like PVD. This drug prevents blood clots from forming, subsequently reducing the risk of adverse cardiac events. However, aspirin’s mechanism of action can backfire, sometimes increasing a person’s risk of hemorrhagic stroke or internal bleeding.

Cardiologist Anthony A Bavry, MD, says that many PVD patients “may not be deriving the benefits from aspirin that they expect to be getting.”

The University of Florida study included a meta-analysis of 11 aspirin therapy trials including more than six thousand PVD patients participating in studies. Statistics gleaned from the 11 trials  showed that aspirin had “no significant effect on death rates and incidents of stroke, heart attack, or major cardiac events.”

"Aspirin might not be a miracle drug for certain patients,” said co-author Ahmed N. Mahmoud, MD. “We need to reconsider the evidence, and see who benefits from aspirin therapy and who does not.”

The present study was published in the journal PLOS One.

Sources: University of Florida, American Heart Association

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
MAR 18, 2021
Microbiology
How a Chronic Hepatitis B Infection Happens
MAR 18, 2021
How a Chronic Hepatitis B Infection Happens
Hepatitis B can cause a long-term and sometimes fatal disease. Princeton University researchers have learned more about ...
MAR 25, 2021
Cardiology
Improved Triage Method to Get STEMI Patients from Door to Treatment
MAR 25, 2021
Improved Triage Method to Get STEMI Patients from Door to Treatment
A heart attack is an incredibly sudden and dangerous cardiac event that requires quick action for a successful recovery. ...
MAR 26, 2021
Cell & Molecular Biology
New 'Bio-ink' Gets 3D-Printed Organs Closer to Reality
MAR 26, 2021
New 'Bio-ink' Gets 3D-Printed Organs Closer to Reality
For the many people waiting for transplants, 3D-printed organs can't come soon enough. Researchers have been making stri ...
APR 01, 2021
Microbiology
Mapping the Wild Microbiome to Search for Therapeutic Agents
APR 01, 2021
Mapping the Wild Microbiome to Search for Therapeutic Agents
Many people think of bacteria as disgusting germs, but there are plenty of important bacterial species that provide us w ...
APR 08, 2021
Clinical & Molecular DX
Marijuana Versus Tobacco: Which Is Worse for Your Lungs?
APR 08, 2021
Marijuana Versus Tobacco: Which Is Worse for Your Lungs?
Canadian researchers have observed that individuals who smoke marijuana are more at risk than tobacco cigarette smokers ...
APR 15, 2021
Immunology
COVID Vaccines Protect Breastfeeding Babies Too
APR 15, 2021
COVID Vaccines Protect Breastfeeding Babies Too
Good news for families of newborns: A new study shows that breastfeeding mothers who receive a COVID vaccine share prote ...
Loading Comments...