OCT 29, 2019 03:33 PM PDT

Immune Protein Prevents Herpes Spreading to the Brain

WRITTEN BY: Kara Marker

An immune protein that was discovered more than two decades ago has been identified as the primary component of a molecular blockade that prevents genital herpes infections from spreading to the nervous system. Scientists involved in this latest research are hopeful that the findings could someday transform into preventative therapies for genital herpes and other inflammatory diseases.

Genital herpes simplex virus 2 (HSV-2) is not to be confused with HSV-1, with is usually characterized as oral herpes and is transmitted by non-sexual means. At least one out of every six people between the ages of 14 and 19 has HSV-2. The disease is transmitted through sexual contact, often even if the person with the virus is not currently experiencing reactivation.

Once infection ensues, the virus spreads to the nervous system where it eventually enters a period of latency. It lives dormantly with periodic reactivations where the infected person experiences genital lesions. New research shows that a specific immune protein is responsible for preventing the virus from continuing through the nervous system and ultimately reaching the brain.

Interleukins are immune proteins vital for relaying cellular messages during the immune response to pathogens. IL-36γ’s role is pro-inflammatory; in 20 years of research, scientists have observed time and time again its role in the inflammatory response during both autoimmunity and pathogenic invasion.

University of Arizona researchers were the first to pinpoint IL-36γ in the female reproductive tract in the context of HSV-2. Most recently, senior author Melissa Herbst-Kralovetz, PhD, explains, they have been evaluating the “extent that this molecule can protect against, or contribute to, genital infection.”

Their study included an experimental group of mice lacking IL-36γ. Without this key immune protein, an HSV-2 infection spread through the nervous system to the brain. In a control group with normal IL-36γ levels, researchers observed “significantly more” protection from HSV-2 neuroinvasion. While the methods by which IL-36γ protects the body from HSV-2 neuroinvasion are still unknown, researchers do know that neutrophil recruitment is part of the story.

Sources: Centers for Disease Control and Prevention, Oncotarget, University of Arizona College of Medicine, Journal of Immunology

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
DEC 10, 2019
Health & Medicine
DEC 10, 2019
Drug-resistant Candida Auris is Spreading
A drug-resistant fungal yeast, Candida auris, is spreading throughout hospitals worldwide. Deemed “an urgent threat” by the Center for Disease...
DEC 10, 2019
Cannabis Sciences
DEC 10, 2019
Can you be Allergic to Cannabis?
Pollen allergies are very common. As cannabis flowers produce, it is also possible to be allergic to cannabis. Here's what to look out for....
DEC 10, 2019
Microbiology
DEC 10, 2019
Gut Microbes may Link Stress and Autoimmune Disease
Stress can have a detrimental effect on our health, and appears to contribute to the development of autoimmune diseases....
DEC 10, 2019
Microbiology
DEC 10, 2019
The Developing Fetus is Exposed to Bacteria in the Womb
Our bodies host many microbes, and scientists have been learning more about the role of this microbiome in our health, and when it is established....
DEC 10, 2019
Cell & Molecular Biology
DEC 10, 2019
How Neutrophils are Involved in Gallstone Formation
Gallstones form in the gallbladder, and can be as tiny as a grain of sand or as big as a golf ball....
DEC 10, 2019
Cell & Molecular Biology
DEC 10, 2019
Scientists Reveal a Link Between Brain Fog and Inflammation
When people get sick, they often also feel tired, which can be as troublesome as their disease....
Loading Comments...