NOV 01, 2019 11:52 AM PDT

Immunity to HPV Can Prevent Skin Cancer

WRITTEN BY: Kara Marker

Scientists discovered a surprise benefit of low-risk human papillomaviruses (HPV), a typical resident of human skin. New research shows that these harmless and common viruses may be protective against skin cancer, making them the primary target of future vaccines to prevent skin cancer.

Low-risk, skin-resident HPV strains are not to be confused with those high-risk HPV strains that affect 79 million Americans as the most common sexually transmitted infection. Of more than 100 total strains, experts consider about 12 HPV strains to be high-risk. HPV infections usually resolve on their own, but in more severe cases, HPV is known to cause genital warts and promote cancer development.

While looking for a causatory link between HPV and squamous cell carcinoma (SCC), researchers actually found evidence suggesting low-risk, skin-resident HPV protect against SCC - not promote its development. This link is particularly important for immunosuppressed individuals who are dramatically more prone to developing cancers like SCC that are linked to viral infection.

Researchers came to their conclusion through trials with experimental mouse models of HPV immunity and skin cancer activity. They also studied human skin cancer tissue samples, observing the “presence and activity of 25 known commensal low-risk HPVs.”

The connection between immunity to low-risk HPVs and protection against SCC suggests a new therapeutic target for skin cancer vaccines: T cells with enhanced immunity to low-risk, skin-resident HPV. T cells are part of the immune process that triggers B cells to produce antibodies against dangerous pathogens.

The potential new vaccine approach would enhance a natural system that’s already in place: building immunity against harmless skin viruses. Plus, the approach could bolster current immunotherapies used to target SCC with “immune checkpoint inhibitors” - roadblocks that prompt the immune system to slow down and target cancerous cells.

"This is the first evidence that commensal viruses could have beneficial health effects both in experimental models and also in humans, and it turns out that this beneficial effect has to do with cancer protection,” explained Shawn Demehri, MD, PhD. “The role of these commensal viruses, in this case papillomaviruses, is to induce immunity that then is protecting patients from skin cancers.”

SCC is the second most common type of skin cancer, affecting cell types in the top-most layer of the skin, the epidermis. The most common type of skin cancer is basal cell carcinoma (BCC); SCC and BCC are both nonmelanoma types of skin cancer and are linked to ultraviolet radiation exposure from the sun in 90% of cases.

Sources: Nature, Massachusetts General Hospital, Centers for Disease Control and Prevention, Skin Cancer Foundation

About the Author
Master's (MA/MS/Other)
I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
NOV 03, 2022
Immunology
A Dietary Fiber Can Affect the Microbiome & Trigger Inflammation
A Dietary Fiber Can Affect the Microbiome & Trigger Inflammation
Inulin is one type of fiber that we consume in our diets, and can be found in fruits, vegetables, and grains including w ...
DEC 21, 2022
Immunology
The Next Generation of Flow Cytometry Controls
The Next Generation of Flow Cytometry Controls
If you work in cell biology or immunology, chances are that you're familiar with flow cytometry. This technique meas ...
DEC 07, 2022
Health & Medicine
Vague Plague: Historically Prevalent Diseases in Popular Culture
Vague Plague: Historically Prevalent Diseases in Popular Culture
Every so often, diseases that ravaged past populations pop up in movies or TV, and every now and again an archaeologist ...
DEC 14, 2022
Clinical & Molecular DX
Scientists Identify Compound that Could Broadly Fight Coronavirus Infections
Scientists Identify Compound that Could Broadly Fight Coronavirus Infections
Researchers at the University of British Columbia have identified a compound that shows promise in targeting a wide rang ...
DEC 18, 2022
Immunology
A Totally New Role for an Immune Molecule is Revealed
A Totally New Role for an Immune Molecule is Revealed
Cytokines are crucial signaling molecules. When members of one family of cytokines called interleukin-1 (IL-1) are expre ...
JAN 16, 2023
Immunology
How the Immune System Tolerates Gut Bacteria
How the Immune System Tolerates Gut Bacteria
Our immune system is built to detect foreign invaders, pathogens, and debris, and eliminate them. So how dies it deal wi ...
Loading Comments...