APR 22, 2020 3:03 PM PDT

Scientists Engineer Custom Antiviral Receptors to Fight COVID-19

WRITTEN BY: Kara Marker

The best offense may be a good defense in the fight against COVID-19. Researchers from the Duke-NUS Medical School are exploring the potential to reinforce the human immune system to become at least one component of a multi-faceted attack against COVID-19. The strategy is derived from immunotherapy approaches that have been successful in the past at treating cancer patients.

Immunotherapy is an approach that harnesses and bolsters an individual’s own immune system, providing necessary tools and empowering the human body to defeat cancer on its own. The same could potentially work for COVID-19, the disease caused by the virus SARS-CoV-2 and which leads to harmful complications for many individuals. Immunotherapy could work to treat COVID-19 and other infectious diseases.

Similar immunotherapies to those used in cancer patients have also been used to treat Hepatitis B (HBV) and other infectious diseases in the past. The technique revolves around extracting and altering important cells from the immune system: T cells.

"We demonstrated that T cells can be redirected to target the coronavirus responsible for SARS. Our team has now begun exploring the potential of CAR/TCR T cell immunotherapy for controlling the COVID-19-causing virus, SARS-CoV-2, and protecting patients from its symptomatic effects," explained senior author Antonio Bertoletti.

In theory, researchers would extract T cells from the circulation of an infected person and return them once they have “pasted” one of two receptor types onto each individual cell:

  1. T cell receptors (TCRs): Receptors naturally found on the surfaces of T cells
  2. Chimeric antigen receptors (CARs): Artificial TCRs created in the lab via mRNA electroporation

Either receptor type boosts T cells’ natural ability to recognize pathogens, like SARS-CoV-2, and cancerous cells. The technique of mRNA electroporation to create CARs “limits their functional activity to a short period of time” to protect patients with chronic viral diseases from “friendly fire” due to an excessive immune response triggered by the immunotherapy.

“We argue that some infections, such as HIV and HBV, can be a perfect target for this therapy, especially if lymphocytes are engineered using an approach that keeps them active for a limited amount of time to minimize potential side effects," explained lead author Dr. Anthony Tanoto Tan.

While there are vaccines to prevent HBV infection, current treatments for existing infections cure less than five percent of patients, as the best that these treatments can do is stop existing virally-infected cells from continuing to replicate.

A few roadblocks temporarily stand in the way from researchers implementing this type of therapy for COVID-19:

  • Need for specialized personnel and equipment
  • Issues with cost-effectiveness
  • Need for indefinite administration of immunotherapy

While researchers work to develop solutions and paths forward, they are considering at least using a combination treatment of anti-viral and CAR/TCR T cell immunotherapy.

Sources: Duke-NUS Medical School, Journal of Experimental Medicine, Journal of the Royal Society of Medicine

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
OCT 12, 2020
Drug Discovery & Development
Researchers Solve Key Problem for Cancer Immunotherapy
OCT 12, 2020
Researchers Solve Key Problem for Cancer Immunotherapy
Cancer immunotherapies are becoming increasingly promising as a standard-of-care treatment. However, despite their promi ...
OCT 24, 2020
Immunology
New CRISPR-Based Imaging Tool Is Going to Be HiUGE
OCT 24, 2020
New CRISPR-Based Imaging Tool Is Going to Be HiUGE
A team of researchers at Duke University have developed an imaging technology for tagging structures at a cellular level ...
NOV 19, 2020
Immunology
Parasitic Worms Help Unravel the Immune Mechanisms Underlying Chronic Disease
NOV 19, 2020
Parasitic Worms Help Unravel the Immune Mechanisms Underlying Chronic Disease
Parasitic worms known as helminths have a complicated relationship with the immune systems of the hosts they invade. Ter ...
DEC 20, 2020
Microbiology
How Do mRNA Vaccines Work?
DEC 20, 2020
How Do mRNA Vaccines Work?
Scientist Katalin Karikó studied mRNA vaccines for years. She spent years getting grant rejections, but has now helped c ...
JAN 12, 2021
Immunology
Killer Control: Engineered Stem Cells Dodge Transplant Rejection
JAN 12, 2021
Killer Control: Engineered Stem Cells Dodge Transplant Rejection
The first organ transplant—performed over 60 years ago—was a success because the donor and recipient were id ...
JAN 13, 2021
Immunology
Antibodies Gain the Upper Hand Against Sly Tumors
JAN 13, 2021
Antibodies Gain the Upper Hand Against Sly Tumors
Tumors use ingenious approaches to stay just out of reach of immune cells on patrol and avoid detection. Indeed, cancer ...
Loading Comments...