JUL 24, 2020 7:21 AM PDT

Telling the Difference Between Eczema and Psoriasis

WRITTEN BY: Kara Marker

It can be extremely different even for professionals to tell the difference between psoriasis, an autoimmune disorder, and atopic dermatitis, also known as eczema. The two conditions share a lot of qualities: appearance, itchiness, even treatment options. A new test from Mount Sinai makes distinguishing between the two a bit easier, relying on biomarkers unique to each condition’s activity in the human body.

Eczema vs. Psoriasis

Eczema is a skin disorder characterized by inflammation and itchy skin, with patches of affected areas usually being near the knees and elbows. More than 31 million Americans live with eczema, including between 10 and 20 percent of children.

Psoriasis is a skin disorder characterized by thick, red, scaly patches that can be found near the knees, elbows, face, buttocks, and scalp. More than eight million Americans live with psoriasis, and there is no known cure.

Diagnosing Eczema & Psoriasis

Historically, diagnosing these conditions and telling the difference between them has relied on problematic skin tissue biopsies. This diagnostic approach is associated with risk of pain, scarring, and increased risk of infection. In the new study, researchers offer a non-invasive alternative: adhesive tape strips that collect skin cells.

The Study

Researchers evaluate tape strips from a total of 60 participants: one-third with moderate to severe eczema, one-third with moderate to severe psoriasis, and 20 healthy adults. Each participant provided 20 tape strips from both lesioned and clinically unaffected skin. Researchers used “global molecular profiling” of skin cells gathered from these strips to identify any sign of biomarkers related to either skin disorder. A single gene biomarker, nitride oxide synthase 2 (NOS2), allowed the team to detect unique cases of psoriasis and eczema with 100 percent accuracy.

Additionally, researchers identified other genes related to eczema, psoriasis, or both conditions, affecting normal immune and skin function. Also, what the researchers observed as far as biomarker activity in each of the two conditions matched with previous research delineating the pathology of each disease.

Sources: The Mount Sinai Hospital / Mount Sinai School of Medicine, Journal of Allergy and Clinical Immunology, American Academy of Dermatology Association, Penn Medicine

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 16, 2020
Immunology
Stronger Skeletal Muscles May Reflect A Sturdy Immune System
JUN 16, 2020
Stronger Skeletal Muscles May Reflect A Sturdy Immune System
Individuals struggling to recover from chronic infections and cancer usually experience reduced immune strength and weig ...
JUL 22, 2020
Immunology
CBD May Reduce Cytokine Storm & Lung Inflammation in COVID-19
JUL 22, 2020
CBD May Reduce Cytokine Storm & Lung Inflammation in COVID-19
Initial studies of cannabidiol’s impact of classic symptoms of lung damage in severe cases of COVID-19 provide a p ...
AUG 05, 2020
Coronavirus
Age-old Immune Components Affecting COVID-19 Severity
AUG 05, 2020
Age-old Immune Components Affecting COVID-19 Severity
One of the most unsettling aspects of the coronavirus pandemic is the wide range of severity those affected seem to expe ...
AUG 27, 2020
Health & Medicine
Africa Eradicates Wild Poliovirus
AUG 27, 2020
Africa Eradicates Wild Poliovirus
On August 25th, Africa was officially certified free of wild poliovirus, a tremendous milestone that was decades in the ...
SEP 11, 2020
Immunology
Could a Drug for Cats Treat COVID?
SEP 11, 2020
Could a Drug for Cats Treat COVID?
Canadian researchers have discovered that a drug used to treat coronavirus infections in cats shows promise in helping C ...
SEP 16, 2020
Immunology
Depression, but Not Anxiety, Causes Inflammation and Metabolic Imbalances
SEP 16, 2020
Depression, but Not Anxiety, Causes Inflammation and Metabolic Imbalances
Scientists have discovered that depressed individuals show higher levels of inflammation as well as elevated fat concent ...
Loading Comments...