DEC 10, 2015 01:12 PM PST

Cell Division Enzyme Plays Dual Role in Inflammatory Pathway

WRITTEN BY: Kara Marker
The NEK7 enzyme has been completely characterized for its role in innate immunity, however until this discovery was made and the study published, scientists were only aware of its role in cell division. In fact, this enzyme also performs a “switch-like” activity that affects inflammation.

NEK7 comes from a family of NIMA-related kinases, a group the controls the initiation of mitosis (Genecards.org). This week, in a study published in Nature Immunology, scientists from UT Southwestern Medical Center (UTSMC) showed that NEK7 also plays a role in the NLRP3 inflammasome pathway, a series of actions studied and revealed in 2014 to activate inflammatory particles to be released from macrophages during a microbial invasion (Nature Immunology).
regulation of the NLRP3 inflammasome pathway

In the UTSMC study, scientists observed mouse models of inflammatory bowel disease and multiple sclerosis, looking to make a connection between NEK7 defects and NLRP3 errors. After extensive genetic screening, NEK7 mutations were clearly linked to NLRP3 defects, and the scientists were able to fully characterize the role of NEK7 in the NLRP3 inflammasome pathway.

Since this pathway activates cytokines that trigger inflammation in response to invading organisms, identifying NEK7 as a component of NLRP3, NEK7’s newly discovered connection to inflammation is thought to have potential for treating medical conditions linked to inflammation.
 
As regulators of mitosis, it makes sense that NIMA-related kinases should be linked to inflammation, and their identifying acronym quite literally means “never in mitosis” (Genecards.org).

“Our work has shown that the inflammasome cannot become activated during mitosis,” said Dr. Bruce Beutler, Director of the Center for the Genetics of Host Defense at UT Southwestern and senior author of the study. He and other researchers speculate that this is designed to protect the dividing cell from DNA damage.


Source: UT Southwestern Medical Center
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 22, 2018
Health & Medicine
JUN 22, 2018
A New Test for Peanut Allergy: Better, Faster, Cheaper.
Scientists from the Medical Research Council (MRC) in the UK have come up with a test to detect peanut allergies and it’s safer, quicker and more acc...
JUL 09, 2018
Immunology
JUL 09, 2018
Protein Complex Determines the Fate of T cells
The protein complex mTORC1 has been shown to integrate metabolic and signaling activity to determine the fate of T cell lineage between alpha beta and gamma delta....
JUL 19, 2018
Microbiology
JUL 19, 2018
Mom's Microbiome has a Big Impact on Kid's Autism Risk
For many years, scientists have been trying to learn more about the causes of autism....
AUG 06, 2018
Immunology
AUG 06, 2018
Maternal Dengue Immunity Protects Against Infant Zika Infection
Maternal Dengue immunity produces CD8+ T cells that protect against fetal Zika infection preventing zika-related malformations....
AUG 08, 2018
Immunology
AUG 08, 2018
Doxorubicin Causes Heart Toxicity by Immune System Disruption
Chemotherapy drug Doxorubicin disrupts metabolism that controls immune responses in the heart leading to heart toxicity....
AUG 28, 2018
Cell & Molecular Biology
AUG 28, 2018
Finding the Source of a Common Immune Cell
Neutrophils are a highly abundant type of immune cell, outnumbering every other kind that runs through the bloodstream....
Loading Comments...