MAR 02, 2017 6:09 PM PST

What Your Asthma Inhaler ISN'T Doing For You

WRITTEN BY: Kara Marker

For individuals with asthma using a metered-dose inhaler (MDI) to prevent or relieve symptoms, there is a good chance that they are not using their inhaler correctly, and subsequently they are not experiencing lung exposure to the pressurized medication needed to ward off asthma attacks.

Rice University researchers found that  found that inhaler patients get the most medicine in their lungs when they inhale deeply for about three seconds and activate the inhaler about a half second after starting to inhale.

Experts from Rice University and Baylor College of Medicine, in their paper recently published in the Journal of Aerosol Medicine and Pulmonary Drug Delivery, point out several flaws in the usage of MDIs that limits the amount of medicine received by more than 50 percent.

Asthma is a common, chronic inflammatory disease that occurs in a range of severity among patients. It is caused by an accumulation of immune cells like eosinophils, mast cells, and others in the various lung tissues that activate, cause inflammation, and lead to the narrowing of the airwaves, and it is exacerbated by a plethora of environmental allergies.

An MDI is a device for delivering bronchodilator drugs to constricted lungs. The most common “rescue medication” is albuterol, a short-acting beta-2 antagonist that causes bronchodilation, which can be used to both prevent and treat acute asthma attacks. The Centers for Disease Control and Prevention (CDC) estimates that over eight percent of the United States population has asthma.

"Metered-dose inhalers are used every day by people with asthma, COPD and other chronic lung diseases, and the vast majority of the time, between 70 and 90 percent, patients make mistakes that keep some of the medicine from making it to their lungs," said study co-author Ashutosh Sabharwal from Rice University. "While inhalers are the most efficient delivery mechanism for many patients, these devices require deft maneuvers on the part of patients. The common errors are well-known, but fixing them continues to be a challenge."

Rice University Scalable Health Lab researchers Ashutosh Sabharwal and Rajoshi Biswas. Source:  Jeff Fitlow/Rice University

Over six years, a PhD student from Rice University and the other co-author on the paper, Rajoshi Biswas, collected information on common user errors made during inhaler usage and how user errors affect the amount of medicine reaching an individual’s lungs. Biswas also designed an experimental setup to mimic how people use inhalers.

"The thing that matters the most is coordination," Biswas said. "It's vital to start breathing just before or at the exact same time the inhaler is activated. A delay of just a half second between pressing the inhaler and breathing in was enough to limit lung deposition to about 20 percent.”

The work done by Biswas and her team of experts represent a need for health officials to revisit the research and update outdated inhaler user guidelines. "The propellant used in inhalers has changed in recent years, and the current guidelines were developed based on studies of the old inhalers,” Sabharwal explained. “Our findings, coupled with the recent changes in inhaler propellants, suggest it is time to revisit these guidelines."

Sources: American Journal of Managed Care, Asthma Society of Canada, CDC, Rice University

 

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
OCT 07, 2021
Cancer
Dual Threat: CAR T Cells Modified to Target Two Neuroblastoma Antigens
OCT 07, 2021
Dual Threat: CAR T Cells Modified to Target Two Neuroblastoma Antigens
Neuroblastoma is a cancer of immature nerve cells found in various areas, including the adrenal glands, neck, chest ...
OCT 19, 2021
Cell & Molecular Biology
Mouse Fathers Passed Immunity Onto Offpsring After Infection
OCT 19, 2021
Mouse Fathers Passed Immunity Onto Offpsring After Infection
Parents pass their genes on to their children. But they can pass down other things too with epigenetic marks, chemical t ...
NOV 04, 2021
Immunology
The Coronavirus Infects Inner Ear Cells
NOV 04, 2021
The Coronavirus Infects Inner Ear Cells
An increasing number of COVID-19 patients have reported ear-related issues: ringing in the ear, hearing loss, and balanc ...
NOV 21, 2021
Microbiology
Rare Genetic Variant Can Make People Susceptible to Bird Flu H7N9
NOV 21, 2021
Rare Genetic Variant Can Make People Susceptible to Bird Flu H7N9
Zoonosis is a serious health concern, as the COVID-19 pandemic has shown. Viruses that infect one species can acquire ge ...
DEC 23, 2021
Immunology
Double Whammy Cytokine Hit Stops Transplant Side Effects
DEC 23, 2021
Double Whammy Cytokine Hit Stops Transplant Side Effects
  Patients who receive bone marrow or stem cell transplants are offered the gift of a new lease of life. However, s ...
DEC 23, 2021
Immunology
Hitting the Anti-inflammatory Bullseye to Treat IBD
DEC 23, 2021
Hitting the Anti-inflammatory Bullseye to Treat IBD
Fifty percent—that’s the percentage of patients with inflammatory bowel disease (IBD) who experience long-te ...
Loading Comments...