APR 11, 2017 10:05 AM PDT

Battling the Cancer Takeover of Immune Cells

WRITTEN BY: Kara Marker

An overwhelming majority of cancer deaths are in some way connected to metastasis even though the immune system is rather effective at scouring the bloodstream for traveling cancer cells. This is because cancer cells have found a way around the ever-watching eye of the immune system, by seizing control of myeloid-derived suppressive cells (MDSCs) from the bone marrow.

Credit: Phil Jones, Senior Augusta University Photographer

"There is a very intricate balance in the immune system that is usually anti-tumorigenic, meaning it eliminates tumors, but in some cases, if this balance is altered, these cells may actually help tumors grow and develop into full-blown metastatic disease," explained Hasan Korkaya, PhD from the Medical College of Georgia at Augusta University.

MDSCs are conveniently capable of suppressing the immune response. While immune regulation is vital in some situations, cancer cells take advantage of MDSCs, using their “powers” for “evil” instead of “good.” MDSCs are found in high levels in mouse models and humans with cancer, and researchers from the Medical College of Georgia are working on unveiling the role of MDSCs in cancer metastasis.

Cancer cells secrete cytokines just like the immune system to communicate with MDSCs, and two different types of MDSCs are evidently useful to the cancer agenda.

  • Monocytic cells facilitate the tumor cell transition into a stem cell-like state to enable them to leave the primary tumor, enter the bloodstream, travel to a new area of the body, and set up camp

  • Granulocytic cells expedite the transition back to cancer cells and the multiplication process to build a new population of tumors

The therapeutic plan of attack is to “re-school” MDSCs to shift their loyalty back to the immune system, attacking cancer cells instead of protecting them. Additionally, researchers are interested in identifying and targeting cytokines used by cancer cells to communicate with MDSCs, literally killing the messenger.

The present study was published in the journal Nature Communications.

Source: Medical College of Georgia at Augusta University

About the Author
I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
SEP 07, 2022
Cell & Molecular Biology
Sequencing Living Cells, Individually, Without Killing Them
SEP 07, 2022
Sequencing Living Cells, Individually, Without Killing Them
When genes in a cell are active, they are transcribed into messenger RNA (mRNA) molecules. So researchers can take a sna ...
OCT 20, 2022
Cancer
Mast Cells Facilitate Metastasis in HR+ Breast Cancer
OCT 20, 2022
Mast Cells Facilitate Metastasis in HR+ Breast Cancer
The gut microbiome describes the microorganisms and viruses that live throughout the digestive system.  The gut mic ...
OCT 28, 2022
Coronavirus
The New GenElute™-E Viral RNA/DNA Kit
OCT 28, 2022
The New GenElute™-E Viral RNA/DNA Kit
Three Advantages: Reduction in plastic use Time savings Better results Nucleic acids play an essential role in the funct ...
NOV 14, 2022
Neuroscience
How COVID-19 Can Disrupt the Brain
NOV 14, 2022
How COVID-19 Can Disrupt the Brain
The virus that causes COVID-19 does not infect neurons, or if it does, that only happens in rare cases. But COVID-19 can ...
NOV 17, 2022
Cancer
Anti-Aging Supplement Linked to Aggressive Breast Cancer
NOV 17, 2022
Anti-Aging Supplement Linked to Aggressive Breast Cancer
Vitamin B3, also known as niacin, is a generic name for a group of biochemical compounds, including nicotinamide ribosid ...
NOV 22, 2022
Microbiology
Flu Killed Mice Eating a Processed Diet, but Spared Those on Grains
NOV 22, 2022
Flu Killed Mice Eating a Processed Diet, but Spared Those on Grains
When researchers have studied infections in animal models, they have typically focused on the pathogen and the host. But ...
Loading Comments...