APR 14, 2017 11:31 AM PDT

New in Immunotherapy: Blocking Cancer Blood Vessels

WRITTEN BY: Kara Marker

Immunotherapy is a method of fighting cancer that revolves around empowering the immune system to reach its full cancer-killing potential. But tumor cells are constantly finding ways to resist and retaliate, so counterattacks are always necessary.

An antibody against ANGPT2 and VEGFA reprograms the tumor blood vessels to facilitate the extravasation of anti-tumoral T cells. Credit: Ella Maru Studio

A growing tumor generates its own system of blood vessels that flood cancer cells with oxygen and nutrients. In addition to providing nourishment, these vessels block the arrival of T cells either naturally sent by the immune system or sent as a result of an immunotherapy to boost T cell activity. Tumors rely on two key proteins to stimulate the growth of their blood vessel network and to keep T cells at bay: VEGFA and ANGPT2.

A new approach designed by experts from the Ecole Polytechnique Federale De Lausanne (EPFL) in Switzerland may be the answer: an antibody called A2V that simultaneously blocks VEGFA and ANGPT2 and metastasis.

"A2V not only regressed most of the tumor blood vessels, but also reversed the aberrant features of those that had remained, making them similar to normal blood vessels and more permissive to the arrival of anti-tumoral T cells,” explained study leader Michele De Palma.

By preventing tumors from reaping the benefits of their blood vessel system, A2V offers a new solution for treating many different types of cancer. However, the EPFL study showed that tumors were quick to answer back with a solution of their own: expression of protein PD-L1 that binds to PD-1 on the surface of T cells to prevent T cells from attacking. Thankfully, scientists have already developed antibodies that serve as checkpoint inhibitors to counter the PD-L1/PD-1 inhibition of T cells.

“Certain anti-angiogenic drugs, namely ANGPT2 inhibitors, have more profound effects on tumors than initially thought,” De Palma explained. “Besides targeting the blood vessels, they also help initiate anti-tumoral immune responses, which can be reinforced by immune checkpoint blockade.”

Based on De Palma’s findings, it seems that scientists are just unveiling the beginning of the potential benefits of applying the A2V antibody. Future studies will illustrate just how valuable this new approach will be for fighting cancer.

The present study was published in the journal Science Translational Medicine. For more on cancer immunotherapy, check out the video below: 

Sources: Ecole Polytechnique Federale De Lausanne (EPFL)

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUL 23, 2018
Immunology
JUL 23, 2018
Obesity Associated Inflammation Leads to Chronic Health Issues
Inflammation caused by harmful oxidized lipids increases in individuals with obesity and may contribute to chronic disease development....
AUG 06, 2018
Immunology
AUG 06, 2018
Maternal Dengue Immunity Protects Against Infant Zika Infection
Maternal Dengue immunity produces CD8+ T cells that protect against fetal Zika infection preventing zika-related malformations....
OCT 24, 2018
Cardiology
OCT 24, 2018
Red Meat Has Been Linked To Increased Risk Of Heart Disease
Researchers have long suspected that allergens can trigger immunological responses that might have an association with plaque buildup and arterial blockage...
OCT 29, 2018
Immunology
OCT 29, 2018
Immunity for All
A study published in Nature has shed light on the evolution of immune system genes across species with great detail at the single-cell level...
NOV 07, 2018
Immunology
NOV 07, 2018
Herd Protection Against Measles
A 26-year-old leukemia patient dies from exposure to measles. Herd immunity can offer a level of protection for those with impaired immune systems....
NOV 14, 2018
Immunology
NOV 14, 2018
Stress in Youth Can Mean Depression as an Adult
A research team investigates early life stress and its relation to adult depression and anxiety...
Loading Comments...