MAY 10, 2017 3:35 PM PDT

Playing Hide and Seek with Latent HIV

WRITTEN BY: Kara Marker

The ability of HIV to hide in the body’s own immune cells is what makes an HIV infection an infection for life. But maybe it doesn’t have to be this way, suggests new research from scientists at the Gladstone Institutes. Novel findings show that an enzyme tied to HIV latency regulation might provide a new option for therapeutic HIV targeting.

Scanning electron micrograph of HIV-1 budding from cultured lymphocyte. The multiple round bumps on cell surface represent sites of assembly and budding of virions.  Credit: CDC

Existing drug therapy for HIV infections, which is not devoid of adverse effects, is characterized by a regimen required indefinitely to keep the virus at bay; there is no guarantee that the drugs will ever completely deplete the population of latent HIV hiding in the body. Latent HIV sets up shop in the body early during HIV infection, hiding in the most unlikely of places: T cells themselves. These viruses remain dormant but essentially act as a backup team if drugs kill the rest of the active troops. While constant drug therapy is one way to combat HIV infection, scientists are now ready for a method of eliminating all signs of HIV within a person once and for all.

The “Shock and Kill” Strategy

Combination of drugs to induce the latent HIV to become active again, draw the virus from out of the shadows where it is more vulnerable. Then, the immune system can target and kill any remaining HIV. This approach may seem like the obvious solution, so why haven’t researchers accomplished it yet? Apparently, reactivating dormant HIV is a difficult task. However, the enzyme SMYD2 seems to be the key to success.

"Our study focused on a class of enzymes called methyltransferases, which have emerged as key regulators of HIV latency," explained senior investigator Melanie Ott, MD, PhD. Ott and her team scanned more than 50 of the methyltransferases to identify SMYD2 as capable of manipulating HIV latency in T cells. Soon after this identification, SMYD2 became the new potential therapeutic target in the fight against HIV.

Ott and her team, alongside partner Warner Greene, MD, PhD, tested molecules that could inhibit SMYD2 and subsequently, reactivate latent HIV hiding in T cells. The tests were successful.

“Our findings provide the basis for a new model of HIV latency wherein SMYD2 contributes to durably repressing the latent virus," said Ott. "Though we are still far from a human application, it is exciting to know that data from this study might readily connect with clinical efforts."

The present study was published in the journal Cell Host & Microbe.

Source: Gladstone Institutes

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog:
You May Also Like
AUG 06, 2019
AUG 06, 2019
Lab Mice Born to Moms From the Wild Make Better Research Models
A standard research mouse genotype was preserved while generating a natural microbiome by using wild mice as surrogates....
SEP 27, 2019
Drug Discovery & Development
SEP 27, 2019
AI Exponentially Accelerates Drug Development
Research and development for new drugs is both an expensive and lengthy process, often lasting years, if not decades. With the development of artificial in...
OCT 17, 2019
Health & Medicine
OCT 17, 2019
STDs Still on the Rise in U.S.
Last week, the Centers for Disease Control and Prevention (CDC) released its annual Sexually Transmitted Disease Surveillance Report, the details of which...
OCT 21, 2019
Drug Discovery & Development
OCT 21, 2019
Effective Vaccines for Lyme Disease?
Currently, there are no effective vaccines available for the presentation of Lyme disease. The only preventive efforts present includes “guiding&rdqu...
DEC 20, 2019
DEC 20, 2019
Does Having Herpes Increase Your Risk for Alzheimer's?
Around 44 million people around the world have Alzheimer’s disease, a progressive form of dementia that leads to memory loss and a decline in cogniti...
FEB 04, 2020
FEB 04, 2020
The Gut Deploys Protective Mechanisms in Coordination with Your Mealtime Habits
At mealtime, every mouthful of food contains a possible risk of incoming pathogens to the digestive system. The gut takes protective measures to account fo...
Loading Comments...