JUN 07, 2017 10:54 AM PDT

Protecting Type 1 Diabetics from Heart Disease with An Extra Insulin Shot

WRITTEN BY: Kara Marker

An additional insulin injection three hours after eating seems to provide a protective effect for type 1 diabetics with heart disease. Normally, insulin doses are based on a meal’s carbohydrate content, but most meals also have fats, which are metabolized more slowly than carbohydrates. Researchers from Leeds Beckett University show the benefit of extra insulin in response to these differences in metabolism rates.

Credit: Fusion Healthcare Staffing

"Many people with type 1 diabetes struggle to regulate their blood sugar levels around mealtimes, because the fat content in their food is metabolised after their standard insulin injection has lost its potency or has left their blood,” explained study co-author Dr. Matthew Campbell.

Increasing levels of fat after a meal leads to higher blood sugar levels (hyperglycaemia), higher levels of fat and inflammatory markers in the blood, and a higher risk of cardiovascular disease. Heart disease is the leading cause of death for people with type 1 diabetes (T1D).

The Leeds Beckett University clinical trial included ten males with T1D. The participants received three meals with identical carbohydrate and protein content. However, fat content varied: one group’s meal contained a low fat content and two groups’ meals contain a high fat content. Blood samples were taken every thirty minutes up to six hours after each meal.

Participants receiving the low fat meal administered their insulin normally based on carbohydrate content. Participants from one high fat meal group did the same. But participants in the second high fat meal group were given an additional insulin injection in addition to the normal injection based on carbohydrate content. The second injection was one-third of the original dose and was administered three hours after eating.

While participants in the first high fat meal group showed significantly elevated levels of sugar, fat, and inflammatory markers six hours after eating, participants in the second high fat meal group showed results similar to the low fat group.

"Improving the sugar and fat levels in the blood after eating is important for the long-term health of the heart and blood vessels,” said co-author Dr. Daniel West. “But calculating insulin injection dose based on carbohydrates alone is clearly too simplistic, as most people eat meals that include fat and protein too."

A larger trial to test the efficacy of an additional insulin injection according to a meal’s fat content is in the works. With better regulation of blood sugar levels and the reduction of fat and inflammatory markers, advising to people with T1D an additional insulin injection could greatly lower the rate of cardiovascular death in diabetics. 

The present study was published in the journal Diabetes and Vascular Disease Research.

Source: Leeds Beckett University

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
FEB 10, 2020
Immunology
FEB 10, 2020
How Cancer Evades the Immune System Time and Time Again
Scientists discovered a new mechanism by which cancer cells evade the immune system to further their own agenda: invade, ...
MAR 19, 2020
Infographics
MAR 19, 2020
All You Need to Know About Coronavirus (CoVID-19)
A new coronavirus, first identified in China in December 2019, has caused an outbreak of respiratory illness that was re ...
APR 07, 2020
Microbiology
APR 07, 2020
Second COVID-19 Vaccine Enters Human Trials
Yesterday, Inovio Pharmaceuticals, Inc. announced that it will begin human trials on a potential vaccine for COVID-19.
APR 15, 2020
Immunology
APR 15, 2020
How Malaria Protects Itself from the Immune System
A specific parasitic species causes the most deaths from malaria: Plasmodium falciparum. This parasite does so by avoidi ...
APR 16, 2020
Health & Medicine
APR 16, 2020
Structural Basis of Receptor Recognition by SARS-CoV-2
As mortality and infection rates rise globally, it appears that SARS-CoV-2, the virus responsible for the COVID-19 pande ...
MAY 07, 2020
Immunology
MAY 07, 2020
New COVID-19 Vaccine Defends Monkeys Against Infection
Researchers from Beijing-based Sinovac Biotech have reported preliminary results of a study into the development of a va ...
Loading Comments...