JUN 07, 2017 10:54 AM PDT

Protecting Type 1 Diabetics from Heart Disease with An Extra Insulin Shot

WRITTEN BY: Kara Marker

An additional insulin injection three hours after eating seems to provide a protective effect for type 1 diabetics with heart disease. Normally, insulin doses are based on a meal’s carbohydrate content, but most meals also have fats, which are metabolized more slowly than carbohydrates. Researchers from Leeds Beckett University show the benefit of extra insulin in response to these differences in metabolism rates.

Credit: Fusion Healthcare Staffing

"Many people with type 1 diabetes struggle to regulate their blood sugar levels around mealtimes, because the fat content in their food is metabolised after their standard insulin injection has lost its potency or has left their blood,” explained study co-author Dr. Matthew Campbell.

Increasing levels of fat after a meal leads to higher blood sugar levels (hyperglycaemia), higher levels of fat and inflammatory markers in the blood, and a higher risk of cardiovascular disease. Heart disease is the leading cause of death for people with type 1 diabetes (T1D).

The Leeds Beckett University clinical trial included ten males with T1D. The participants received three meals with identical carbohydrate and protein content. However, fat content varied: one group’s meal contained a low fat content and two groups’ meals contain a high fat content. Blood samples were taken every thirty minutes up to six hours after each meal.

Participants receiving the low fat meal administered their insulin normally based on carbohydrate content. Participants from one high fat meal group did the same. But participants in the second high fat meal group were given an additional insulin injection in addition to the normal injection based on carbohydrate content. The second injection was one-third of the original dose and was administered three hours after eating.

While participants in the first high fat meal group showed significantly elevated levels of sugar, fat, and inflammatory markers six hours after eating, participants in the second high fat meal group showed results similar to the low fat group.

"Improving the sugar and fat levels in the blood after eating is important for the long-term health of the heart and blood vessels,” said co-author Dr. Daniel West. “But calculating insulin injection dose based on carbohydrates alone is clearly too simplistic, as most people eat meals that include fat and protein too."

A larger trial to test the efficacy of an additional insulin injection according to a meal’s fat content is in the works. With better regulation of blood sugar levels and the reduction of fat and inflammatory markers, advising to people with T1D an additional insulin injection could greatly lower the rate of cardiovascular death in diabetics. 

The present study was published in the journal Diabetes and Vascular Disease Research.

Source: Leeds Beckett University

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
NOV 14, 2019
Immunology
NOV 14, 2019
When the Cell Dials 9-1-1
Researchers can now explain how a cell that is being attacked by bacteria or viruses specifically manages to 'sound the alarm'...
NOV 14, 2019
Health & Medicine
NOV 14, 2019
Tick-Borne Diseases Are Rapidly Rising in the U.S.
Tick-borne diseases have significantly increased in the U.S. in the past few years. In 2016 there were 48,610 reported cases and in 2017 59,349; these...
NOV 14, 2019
Health & Medicine
NOV 14, 2019
Blood-Brain Barrier Impairment and Its Role in Alzheimer's Disease
In healthy people, the blood-brain barrier (BBB), which is fromed by brain endothelial cells, strictly controls the entrance of harmful materials into...
NOV 14, 2019
Immunology
NOV 14, 2019
New Observations of a Cancer Transcriptase
New research shows a transcriptase that helps time cell death varies in expression, and is unusually localized, in cancer cells.  The transcriptase, T...
NOV 14, 2019
Drug Discovery & Development
NOV 14, 2019
Researchers Can Now Reverse Skin Cancer
Ten years ago, just 5% of people with advanced melanoma (skin cancer) lived more than five years after being diagnosed. Now however, researchers from the I...
NOV 14, 2019
Infographics
NOV 14, 2019
Surface Plasmon Resonance (SPR) Technology
Surface plasmon resonance (SPR) allows researchers to investigate different types of biomolecular interactions and mechanisms in real-time and label-free....
Loading Comments...