JUN 28, 2017 12:01 PM PDT

Stem Cells Treat Asthma?

WRITTEN BY: Kara Marker

A new treatment for chronic asthma could help people who don’t respond to the standard corticosteroids, who don't have any other options. A new breed of stem cells appears to be the answer, cells capable of reversing the negative effects of asthma on lung tissue.

The new approach to treating chronic asthma is based on induced pluripotent stem cell-derived mesenchymal stem cells (MSCs) from Cynata Therapeutics, an Australian “clinical-stage stem cell and regenerative medicine company.”

What are induced pluripotent stem cells, and what makes them a promising component of a new asthma treatment? These types of stem cells can be directly acquired from adult stem cells and can differentiate (transform into) other types of cells, such as lung cells to recharge lung tissue damaged from chronic asthma.

From Monash University in Australia, researchers tested the therapeutic effect of MSCs - delivered intranasally - in a model of experimental asthma, examining their influence on three components of asthma: inflammation, airway remodeling, airway hyperresponsiveness (the classic symptom of asthma). How effective are MSCs at treating these components? Quite. MSCs reduced inflammation, reversed negative effects of airway remodeling, and returned lung tissue scarring and hyperresponsiveness back to its normal state.

"When we've tested other types of stem cells they haven't been able to fully reverse scarring and lung dysfunction associated with asthma - we've had to combine them with anti-scarring drugs to achieve that,” explained lead researcher Chrishan Samuel. “These cells were remarkable on their own as they were able to effectively reverse the scarring that contributes to lung dysfunction and difficulty in breathing.”

Turned into a new treatment option, MSCs could either provide a new chance for asthma patients not responding to standard corticosteroid therapy or a completely new treatment for people who simply want another choice. In the future, MSCs as an asthma treatment will be tested in comparison to and in combination with standard corticosteroid treatments.

The present study was published in the FASEB Journal.

Source: Monash University

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
FEB 23, 2020
Immunology
FEB 23, 2020
New discovery could help preterm babies breathe easy
Babies born more than three weeks before full term are met with complicated and often life-threatening health challenges ...
MAR 23, 2020
Drug Discovery & Development
MAR 23, 2020
Is Fast-Tracking Vaccines for Coronavirus Really Such a Good Idea?
Donald Trump has called on researchers to “slash red tape like nobody has even done it before” to accelerate ...
APR 13, 2020
Drug Discovery & Development
APR 13, 2020
Are COVID-19 Antibody Tests a Back-to-Work Pass?
Although treatments and vaccines against COVID-19 may still be months away, antibody tests are becoming more widespread. ...
APR 21, 2020
Drug Discovery & Development
APR 21, 2020
Researchers Develop COVID-19 Nasal Spray Vaccine
Researchers from the University of Waterloo in Canada are working on a DNA-based vaccine for COVID-19 that can be applie ...
MAY 21, 2020
Drug Discovery & Development
MAY 21, 2020
Molecular 'Switch' Makes Autoimmune Drugs Fight Cancer
Researchers from the Antibody and Vaccine Group at the University of Southampton, England, have identified a way to repu ...
MAY 16, 2020
Neuroscience
MAY 16, 2020
Stem Cell Method (Parkinson's) Could Avoid Transplant Rejection
Researchers at McLean Hospital and Massachusetts General Hospital (MGH) have tested a stem cell treatment method that av ...
Loading Comments...