APR 08, 2016 4:31 PM PDT

New mouse model for Zika research

WRITTEN BY: Kerry Evans
Researchers at Washington University School of Medicine developed a mouse model of Zika infection. This model can be used to test vaccines and treatments for the virus.

As of this month, the WHO stated that Zika is likely a cause of microcephaly in infants and Guillain-Barré syndrome in some aults. Zika has also been linked to spontaneous abortion and stillbirth. Most cases of Zika in adults are asymptomatic, but 1 in 5 individuals experience a rash and fever. Zika is most commonly spread by the Aedes aegypti mosquito and there is some evidence it may be sexually transmitted.
 
Mice can now be used to study Zika infection.

This new mouse model of Zika infection is one of the first to be established since 1976. Previous models were not clinically relevant because they required the virus to be injected directly into the brain to establish infection. In the new model, mice can be infected through the skin, mimicking infection via a mosquito bite.

Because Zika does not normally infect mice, the researchers had to engineer immune-deficient mice that would be susceptible to the virus. These immune-deficient mice lacked the interferon receptor gene Ifnar1.

The researchers then infected mice with various strains of Zika. The immune-deficient mice died within 10 days, regardless of the strain used. As in humans, the virus accumulated in the brains and spinal cords of the mice. Curiously, they also found virus in the testes of mice, lending support to the idea that Zika can be sexually transmitted.

Wild type mice survived, unless they were infected as newborns; human infants are also susceptible to Zika, but adults are usually not affected. According to study author Michael Diamond, “it appears that pregnant women infected with Zika can pass the virus to babies in utero and that newborns also may be susceptible to infection … other than in infants, we don't really see severe disease in most people with Zika, except for a small fraction who develop Guillian-Barré”.
 

Source: Cell Host & Microbe, Science Daily, Wikipedia, WHO
 
About the Author
  • Kerry received a doctorate in microbiology from the University of Arkansas for Medical Sciences.
You May Also Like
MAY 05, 2020
Microbiology
How a Microbe May Help Stop the Spread of Malaria
MAY 05, 2020
How a Microbe May Help Stop the Spread of Malaria
Scientists have discovered a bacterium that lives in mosquitoes around Lake Victoria, and appears to block malaria.
MAY 06, 2020
Cell & Molecular Biology
SARS-CoV-2 Can Infect Intestinal Cells
MAY 06, 2020
SARS-CoV-2 Can Infect Intestinal Cells
Once thought to cause symptoms that primarily affect the respiratory system, there has been evidence that the virus can ...
JUN 22, 2020
Cell & Molecular Biology
Viruses Can Create New Genes By Stealing Bits of Human DNA
JUN 22, 2020
Viruses Can Create New Genes By Stealing Bits of Human DNA
When viruses infect cells, they hijack the machinery inside and start to use it for their own purposes. This enables vir ...
JUL 03, 2020
Cell & Molecular Biology
A Gut Pathogen Moves With Help From Its Environment
JUL 03, 2020
A Gut Pathogen Moves With Help From Its Environment
Campylobacter jejuni is a foodborne bacterial pathogen that causes millions of cases of food poisoning each year.
JUL 17, 2020
Neuroscience
RNA Gene Editing Restores Rett's Syndrome Protein in Mouse Model
JUL 17, 2020
RNA Gene Editing Restores Rett's Syndrome Protein in Mouse Model
Video:  Overview of how scientists edit an RNA sequence.    Rett's syndrome is a chronic, neurologica ...
JUL 13, 2020
Drug Discovery & Development
Potential Therapy for The Dengue Virus
JUL 13, 2020
Potential Therapy for The Dengue Virus
Researchers at the University of Texas Medical Branch at Galveston have uncovered a new antiviral mechanism for the new ...
Loading Comments...