SEP 30, 2016 11:17 AM PDT

Fungus makes mosquitoes susceptible to malaria parasite

WRITTEN BY: Kerry Evans
This just in, there’s a fungus that makes mosquitoes more susceptible to malaria. Researchers at the Johns Hopkins Bloomberg School of Public Health found that the fungus - Penicillium chrysogenum - impairs a mosquito’s immune system. If you have a soft spot for mosquitoes, you’ll be happy to know that this fungus doesn’t actually make the little guys sick.
Electron microscopy of Penicillium chrysogenum.
First, a quick review of malaria. Humans get malaria when they are bitten by an Anopheles mosquito that is infected with the Plasmodium parasite. Malaria is, as you no doubt know, a big deal. The World Health Organization reports that in 2015 there were around 214 million cases of the disease worldwide. Among those cases, roughly 438,000 people died. There’s no vaccine for malaria (although researchers are working toward one). Until then, the use of bed nets is the best way to prevent the transmission of malaria.

So, how did researchers first identify this fungus? They isolated it from the midgut of Anopheles mosquitoes in Puerto Rico. Although this type of fungus is considered non-pathogenic, they wanted to know if it impacted mosquito survival in any way.

They added the fungus to a sucrose solution and fed it to mosquitoes. Then, they measured mortality over a 14-day period. The fungus had no effects on mosquito mortality. The next question was whether this fungus had any effect on Plasmodium infection - certain bacteria can cause mosquitoes to be resistant to Plasmodium, for example.

Once again, the researchers fed mosquitoes a sucrose solution containing the fungus. Then, they fed the mosquitoes a blood meal containing Plasmodium gametocytes. Surprisingly, the presence of the fungus in the mosquito midgut increased the number of Plasmodium oocysts found in the mosquitoes.

So, what about the fungus causes this to happen? The group found that the fungus secretes a heat-stable factor that affects Plasmodium infection. They came to this conclusion by heat-treating the fungus culture filtrate - once heat-treated, the filtrate did not enhance Plasmodium infection in the mosquitoes.

There’s more work to be done, but this is a pretty neat example of how microorganisms can affect each other (even indirectly). Not to mention, these findings could help researchers devise new methods and therapies that control malaria transmission. According to study author George Dimopoulos, “While this fungus is unlikely to be helpful as part of a malaria control strategy, our finding significantly advances our knowledge of the different factors that influence the transmission of malaria.”

Sources: Nature, Science Daily
About the Author
  • Kerry received a doctorate in microbiology from the University of Arkansas for Medical Sciences.
You May Also Like
OCT 19, 2019
Cell & Molecular Biology
OCT 19, 2019
A Virus Can Create a Sophisticated Transport System in Bacteria
Bacteria are turning out to be more complex than once thought....
OCT 19, 2019
Cardiology
OCT 19, 2019
Stem Cells Improve Post Infarction Repair
Following a heart attack, tissues within the heart are often damaged. Once damaged, the heart is incapable of regeneration of these tissues. These dead are...
OCT 19, 2019
Microbiology
OCT 19, 2019
Parasitic Worm Capable of Infecting People Now Found in Dogs
There are some small roundworms, also called nematodes, in the genus Strongyloides that can infect animals. Two species can infect people....
OCT 19, 2019
Cell & Molecular Biology
OCT 19, 2019
Researchers Discover a Cause of Antibiotic Resistance
For years, people have relied on antibiotics to cure bacterial infections, and many of those antibiotics are now becoming less effective....
OCT 19, 2019
Immunology
OCT 19, 2019
Researchers Identify Pair of "Recruiters" that Pull T Cells to the Lungs
How do CD8 T cells make it to the lungs to help in the fight against infection? Why don’t T cells remain longer in the lungs? How can science optimiz...
OCT 19, 2019
Microbiology
OCT 19, 2019
Using CRISPR to Alter or Kill Bacteria
In recent years, the gene editing tool CRISPR/Cas9 has been applied to a wide variety of different organisms, and now, bacteria....
Loading Comments...