OCT 08, 2016 5:16 PM PDT

Gut Microbes can Assist Chemotherapy Drugs

WRITTEN BY: Carmen Leitch
Humans have a symbiotic relationship with microorganisms, many of which reside in our gastrointestinal tract, and they can be highly beneficial to our health. New work, reported in the journal Immunity, has indicated that there are two species of bacteria in our gut that can activate cells of our immune system to increase the efficacy of a common anticancer therapeutic. 
 
Scanning electron micrograph of a human T cell / Credit: Wikipedia

The bacteria, Enterococcus hirae and Barnesiella intestinihominis, have a role in the activation of immune responses to cancer that involve T cells, which boosts the effects of a chemotherapy drug. The researchers found that the microbe-assisted immune response led to longer survival without additional cancer growth in patients with advanced lung and ovarian cancer that have been given chemo-immunotherapy.

"The anti-cancer drug's efficacy relies on a complex interplay between the microbiome of cancer patients and their ability to mount an efficient immune memory response against some bacteria of the gut microbiota," explained the co-senior author of the study, Mathias Chamaillard, Research Director of the Center for Infection and Immunity of Lille (Inserm/CNRS/Lille University/Institut Pasteur de Lille). "This paradigm opens the way to improve treatment design by either optimizing the use of antibiotics, or implementing supplementation with so-called oncomicrobiotics or their bioactive metabolites, to promote the efficacy of anti-cancer drugs."

Previous work has demonstrated that some gut microbes are able to encourage the growth of tumors, but some are protective against cancer. While in some cases intestinal bacteria can improve the impact of chemotherapy agents, the mechanism this process has remained unclear, as has the identity of the bacterial species that are able to do so. 
 
E. hirae restored the efficacy of CTX in antibiotics-treated mice, E. hirae and B. intestinihominis enhanced cognate anticancer immune responses, NOD2 receptors limit the bioactivity of E. hirae and B. intestinihominis / Credit: Immunity Daillère et al

This new research has shown that E. hirae and B. intestinihominis both work to orchestrate the effects of the chemotherapy drug cyclophosphamide, which is an immunosuppressant used to treat many different types of cancers. The abstract for the publication is shown in the image above. Mouse models were utilized to illustrate that after oral treatment with E. hirae, the antitumor T cell response was activated  in the spleen along with the direct lethal effects of cisplatin on a tumor, thus reducing tumor growth. A similar effect was shown in oral treatment of B. intestinihominis;  T cells infiltration of various mouse tumors was promoted.

To follow up on the results, the blood T cell responses of 38 patients with advanced lung and ovarian cancer and chemotherapy treatment were analyzed. The investigators learned that memory T cell immune responses specific to E. hirae and B. intestinihominis predicted progression-free survival - the amount of time that a patient lives has the disease, but without it getting worse, during and after treatment.

The researchers hope to identify the exact microbial metabolites or molecules impacting the immune system that can enhance the effects of cyclophosphamide. "Answering this question may provide a way to improve the survival of cyclophosphamide-treated cancer patients by supplementing them with bacterial-derived drugs instead of live microorganisms," Chamaillard concluded.

Sources: Eurekalert!/AAAS via Cell Press, Immunity
About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
DEC 10, 2020
Clinical & Molecular DX
Gut Feeling: Microbiome Reveals Toxic Chemical Exposure in Kids
DEC 10, 2020
Gut Feeling: Microbiome Reveals Toxic Chemical Exposure in Kids
A study by Duke University researchers has revealed that children’s gut microbiomes hold clues as to their possibl ...
DEC 21, 2020
Genetics & Genomics
Tracing the Evolution of a Deadly Microbe
DEC 21, 2020
Tracing the Evolution of a Deadly Microbe
Salmonella are human & animal bacterial pathogens that are found everywhere. When the bacterium infects a person, it cau ...
JAN 04, 2021
Microbiology
Some Microbes Could Help Treat Type 2 Diabetes
JAN 04, 2021
Some Microbes Could Help Treat Type 2 Diabetes
The microbial community in our gastrointestinal tract has been shown to have a significant impact on our health and well ...
FEB 16, 2021
Microbiology
A Virus That Can Target and Eliminate Specific Bacteria
FEB 16, 2021
A Virus That Can Target and Eliminate Specific Bacteria
Viruses that infect bacteria are called phages, and scientists have been interested in whether they can be used to targe ...
FEB 24, 2021
Microbiology
The Human Gut Microbiome is Teeming With Viruses
FEB 24, 2021
The Human Gut Microbiome is Teeming With Viruses
Using metagenomics tools, which sequence all of the viral material in a sample, researchers have investigated the viruse ...
FEB 24, 2021
Cell & Molecular Biology
Ancient Fungi Found in Europe's Largest Impact Crater
FEB 24, 2021
Ancient Fungi Found in Europe's Largest Impact Crater
Long ago, fungi colonized the impact crater of an ancient meteor. It seems they may have begun working in partnership wi ...
Loading Comments...