NOV 06, 2016 11:15 AM PST

Good gut Microbes Secrete Protective Proteins

WRITTEN BY: Carmen Leitch
Humans live in a symobiotic relationship with gut microbes, many of which inhabit our gastrointestinal tract. Some of the microbes there can be quite beneficial and important to our health. Some evidence has been found that the right balance of the proper microorganisms can help with digestive ailments. New work done by researchers at the University of California, Irvine (UCI) has indicated that some gut microbes release molecules that could help with intestinal inflammation caused by pathogenic bacteria. The video below describes the work.
 


In a report published in the journal Nature, Manuela Raffatellu, a UCI Associate Professor of Microbiology & Molecular Genetics, and her team demonstrate that beneficial gut microbes, in this case a strain of Escherichia coli called Nissle 1917, releases microcins, small peptides that have an antibacterial effect. The sercetion of microcins can play an important role in preventing some bacteria from causing illness is intestines that are inflamed.

Nissle 1917 is a non-pathogenic strain of bacteria that has been well characterized and has been described as a probiotic - a live microbe intended to have a positive impact on health - for many years. It has also been used in the treatment of bowel disorders for a long time. In this work, the investigators show that the microcins from Nissle 1917 have an inhbitory effect on both salmonella and an pathogenic form of E. coli taken from patients with inflammatory bowel disease.

"Although an in vivo role for microcins has been suggested for 40 years, it has never been convincingly demonstrated," said Raffatellu, who is affiliated with the Institute for Immunology at UCI. "We hypothesize that their role was missed because, as our data indicate, microcins do not seem effective in noninflamed intestines. In contrast, we show that in an inflamed intestine, microcins help a probiotic strain limit the growth of some harmful bacteria."

Raffatellu added that the microcins are needed for the therapeutic effects of E. coli Nissle 1917. The researchers now plan to purify the microcins and then test to see if they can be used as a targeted antibiotic.
 


While many studies have been done, and probiotics have been used by people for decades, the health benefits of probiotics are still under debate. There is a lack of reliable data from the research that has been performed; much of it was not well-designed. The video above, from Argonne National Laboratory, features Dr. Julie Bubeck Wardenburg from the University of Chicago and Professor Susan Erdman from MIT discussing the effects of microbes on humans as well as what will be required to draw real conclusions about probiotics. 

Sources: AAAS/Eurekalert! via UCI, Natural Product Reports, Inflammatory Bowel Diseases - Wolters Kluwer Health, Nature
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
SEP 29, 2018
Microbiology
SEP 29, 2018
In a First, Rat Variation of Hepatitis E Found in a Person
It was found in a 56-year-old Hong Kong man....
OCT 02, 2018
Drug Discovery
OCT 02, 2018
Mycobacterial Lung Disease, FDA Approves New Drug
New drug seeking to treat antibiotic-resistant lung disease has just been approved by the U.S. Food and Drug Administration. The drug is called ‘Arik...
OCT 12, 2018
Videos
OCT 12, 2018
Don't Mess With Microbes
Researchers demonstrate why antibiotics should not be used casually....
OCT 22, 2018
Videos
OCT 22, 2018
How Many Bacteria are There in the World?
Researchers once thought that there were only a few thousand bacterial species on the planet - a gross underestimation....
NOV 23, 2018
Videos
NOV 23, 2018
Another Food Recall: Ground Turkey
The USDA announced that Jennie-O has recalled about 147,276 pounds of its ground raw turkey products....
NOV 25, 2018
Microbiology
NOV 25, 2018
Researchers Learn How Hantavirus Infects Cells
First identified in 1993, hantavirus infections can cause dangerous and potentially deadly respiratory infections....
Loading Comments...