SEP 14, 2017 7:14 AM PDT

With This Pathogenic Microbe, Time is a Factor

WRITTEN BY: Carmen Leitch
Our bodies have an internal clock, the circadian rhythm, and our physiology changes according to that clock. New work suggests that time of day matters to one kind of parasitic infection as well. Researchers at McGill University have found evidence that the parasite that causes leishmaniasis causes infections of varying severity, which depends on whether the infection occurs at night or in the daytime. This research could help develop new treatment strategies for parasitic diseases.
 
Sandflies such as this P. papatasi, are responsible for the spread of the vector-borne parasitic disease leishmaniasis, which is caused by the obligate intracellular protozoa of the genus Leishmania. / Credit:Centers for Disease Control and Prevention/Wikimedia Commons
 
The scientists worked with Leishmania, a parasite that the female sandfly transmits at night. Leishmania is responsible for sickening around one million people every year and kills thousands. Many of those that survive the infection are left with scarring. While it is currently considered a tropical disease, changes in our climate are enabling many species to move to and survive in new areas. It may not be long before this parasitic infection makes it way to many other regions, and it can already be newly found in southern European.
 
This work, led by Nicolas Cermakian, a Professor at McGill's Department of Psychiatry and researcher at the Douglas Institute, used a mouse model to analyze the effects of the parasite. It was injected into mice at different times of day, and the researchers observed that the immune response was very different depending on what time the exposure occurred.
 
"Our previous work showed that our immune system has its own biological clocks. Our body's defense mechanisms are more or less active at different times of the day," explained Cermakian, who collaborated with McGill/RI-MUHC Professor Martin Olivier and Professor Nathalie Labrecque of Université de Montréal and Maisonneuve-Rosemont Hospital research center on this project.
 
The results of the work, published in Scientific Reports, were intriguing. A former postdoc in Cermakian's lab, Silke Kiessling, found the parasitic infection to be most effective during early night time when the immune response was also the most powerful. Apparently, the parasite grows best when it causes a strong immune response. The inflammatory cells of the immune system that rush to the site then help the parasite to multiply.
 
Next, the researchers plan to investigate the molecular mechanisms underlying the circadian rhythm of Leishmania. They have already determined that the immune cells have a clock of their own that directs the response to the parasite.
 
Cermakian is hopeful that this research will not only lead to better treatments and improvements in preventative measures but might also be extrapolated to other diseases that are spread by insects.
 
Learn more about a severe form of Leishmaniasis, considered a neglected tropical disease, from the following video.
 

 

 
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
JUL 07, 2020
Immunology
A Step Towards a Cure for Rare Polio-Like Disease in Children
JUL 07, 2020
A Step Towards a Cure for Rare Polio-Like Disease in Children
Acute flaccid myelitis, or AFM, is a rare but devastatingly debilitating neurologic disease in children caused by a resp ...
JUL 26, 2020
Microbiology
Ongoing Salmonella Outbreak Rapidly Spreads to 23 States
JUL 26, 2020
Ongoing Salmonella Outbreak Rapidly Spreads to 23 States
The CDC has announced that an outbreak of infections related to a strain of the bacterium Salmonella is "rapidly growing ...
JUL 30, 2020
Clinical & Molecular DX
Laser Beams Vibrate Viruses to Distinguish Them
JUL 30, 2020
Laser Beams Vibrate Viruses to Distinguish Them
  In light of the ongoing COVID-19 pandemic, the importance of rapid viral diagnostics has really hit home. Classic ...
AUG 17, 2020
Microbiology
Ingestible Bacteria-Catcher Could Act as a Diagnostic Tool
AUG 17, 2020
Ingestible Bacteria-Catcher Could Act as a Diagnostic Tool
Microbes in our gastrointestinal tract may not only be closely linked to our health, but they may also be useful as a di ...
AUG 27, 2020
Microbiology
Underground Microbes Use an Ancient Form of Energy Production
AUG 27, 2020
Underground Microbes Use an Ancient Form of Energy Production
Organisms rely on a biological fuel known as ATP, which provides the energy for many processes. In cellular respiration, ...
SEP 09, 2020
Cell & Molecular Biology
Why Liver Gene Therapies Have Not Worked & How to Improve Them
SEP 09, 2020
Why Liver Gene Therapies Have Not Worked & How to Improve Them
Diseases that are caused by errors in a gene might be cured if we could correct those errors, or genetic mutations.
Loading Comments...