FEB 13, 2016 10:54 AM PST

Scientists turn violent rage on and off in mice

New evidence shows mice have a brain structure that throttles rage.

The structure is called the lateral septum. It’s physically connected to and receives electrical signals other parts of the brain that control emotions, learning, aggression, and hormone production.
 
By "exciting" selected groups of brain cells with light from a surgically inserted probe, researchers could start, stop, and restart aggressive outbursts in the study mice.

Damage to the lateral septum can trigger a cascade of activity in other brain regions that produced “septal rage.” These sudden, violent acts, mostly attacks on other mice, have long been seen in rodents with a damaged lateral septum, and in some birds, researchers say.

“Our latest findings show how the lateral septum in mice plays a gatekeeping role, simultaneously ‘pushing down the brake’ and ‘lifting the foot off the accelerator’ of violent behavior,” says study senior investigator Dayu Lin, an assistant professor at New York University.

Lin emphasizes that septal rage is not known to occur in humans, but that studying male aggression in mice might help to map the circuitry involved in controlling other forms of aggression, including violent behavior in humans.

Among the study’s key findings was that stimulating brain cells in the lateral septum controlled other brain cells, notably in a centrally located region of the hypothalamus, identified anatomically as the ventrolateral part of the ventromedial hypothalamus.

Previous research by Lin had shown this brain region to be highly active during natural aggression but, until now, had not identified the other parts of the brain that interact with it in this context.
 

 

Start, stop, and restart rage


By “exciting” selected groups of brain cells with light from a surgically inserted probe, Lin and her colleagues changed the activity of cells in the lateral septum, and found that they could start, stop, and restart aggressive outbursts in the study mice.

According to Lin, interrupting the connection between the lateral septum and ventromedial hypothalamus did not affect the mice’s sexual behavior, and did not in other experiments stop male mice from attempting to have sex with female mice.

This is important, Lin says, because it demonstrates that two innate behaviors, aggression and sexual behavior, can be adjusted separately.
 

Smart gatekeeper


The scientists also found that when excited, lateral septum cells increased activity in one set of brain cells in the ventrolateral part of the ventromedial hypothalamus, even as they decreased activity in another nerve cell set in the same region.

Indeed, the cells most active during mice attacks were those suppressed to the greatest degree during septal stimulation, while the cells suppressed during aggression were most active when the lateral septum was stimulated. Lin says this finding suggests that the lateral septum is a “smart” gatekeeper of aggression, suppressing attack-excited cells while activating attack-inhibited cells.

“Our research provides what we believe is the first evidence that the lateral septum directly ‘turns the volume up or down’ in aggression in male mice, and it establishes the first ties between this region and the other key brain regions involved in violent behavior,” says Lin.

The research team next plans to investigate which specific brain cells in the lateral septum control male aggression, and under what conditions they are activated to promote or halt the behavior. Lin says her long-term goal is to determine whether or not therapeutic means can be found to control aggression without compromising other social and cognitive functions.

The National Institute of Mental Health, the Ester A. and Joseph Klingenstein Fund, Whitehall Foundation, Sloan Foundation, McKnight Foundation, and Mather’s Foundation supported the research, which appears in Current Biology.

Source: NYU

This article was originally posted on futurity.org.
About the Author
  • Futurity features the latest discoveries by scientists at top research universities in the US, UK, Canada, Europe, Asia, and Australia. The nonprofit site, which launched in 2009, is supported solely by its university partners (listed below) in an effort to share research news directly with the public.
You May Also Like
MAY 22, 2020
Neuroscience
Diesel Fumes Increase Risk for Developing Parkinson's
MAY 22, 2020
Diesel Fumes Increase Risk for Developing Parkinson's
Around 10 million people worldwide have Parkinson's disease, a progressive nervous system disorder that affects move ...
MAY 16, 2020
Neuroscience
Stem Cell Method (Parkinson's) Could Avoid Transplant Rejection
MAY 16, 2020
Stem Cell Method (Parkinson's) Could Avoid Transplant Rejection
Researchers at McLean Hospital and Massachusetts General Hospital (MGH) have tested a stem cell treatment method that av ...
JUN 15, 2020
Cannabis Sciences
Prenatal Cannabis Exposure Does Not Cause Brain Damage in Children
JUN 15, 2020
Prenatal Cannabis Exposure Does Not Cause Brain Damage in Children
Parents and their children often face separation and other punishments due to the idea that prenatal cannabis exposure c ...
JUN 24, 2020
Health & Medicine
Best Not Get Behind the Wheel After Indulging in Recreational Marijuana
JUN 24, 2020
Best Not Get Behind the Wheel After Indulging in Recreational Marijuana
Two new studies examining the effects of recreational marujiana on road deaths have been published in the June issue of ...
JUL 09, 2020
Immunology
Infection During Pregnancy Could Trigger Autism in Children
JUL 09, 2020
Infection During Pregnancy Could Trigger Autism in Children
Researchers from the Center for Neuroscience at the University of California, Davis have revealed new insights into the ...
JUL 17, 2020
Neuroscience
RNA Gene Editing Restores Rett's Syndrome Protein in Mouse Model
JUL 17, 2020
RNA Gene Editing Restores Rett's Syndrome Protein in Mouse Model
Video:  Overview of how scientists edit an RNA sequence.    Rett's syndrome is a chronic, neurologica ...
Loading Comments...