APR 08, 2017 4:17 PM PDT

Newly Discovered Protein can Boost Vaccine Efficacy

WRITTEN BY: Carmen Leitch

A newly found protein may aid vaccinations; it could make them more effective and could expand their use for other diseases. The protein, PorB, was detected in the membrane of a neisseria meningidis bacterium. The scientists demonstrated that it improved vaccines by stimulating the cells of the immune system to kill foreign invaders as well as stimulating the production of antibodies. The work was published in Scientific Reports.

"Our study deepens the general understanding of how vaccine adjuvants modulate immune responses," commented Dr. Lee Wetzler, a Professor of Medicine and Microbiology at Boston University Medical School. "The antigen formulation with PorB triggers a sequence of cellular events at the periphery and in lymphoid tissue that are critical for the establishment of protection to a broad array of infectious diseases, and maybe for other diseases like cancer."

The researchers used two models, one that only got a vaccine with an antigen, one that received that plus PorB. That showed the addition of PorB was able to stimulate an increase in the number of activated cells in the lymph nodes and an increase in cytotoxic T cell production.

"This study has wide implications as it could not only be used to help the body identify and fight off bacterial infections, but it could also potentially help the body use its own machinery to fight off other diseases like cancer, HIV, and influenza before they have a chance to establish within the body," Wetzler concluded.
About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
NOV 07, 2020
Space & Astronomy
Scientists Detect Origin of Fast Radio Burst in Milky Way
NOV 07, 2020
Scientists Detect Origin of Fast Radio Burst in Milky Way
Scientists have identified a burst of cosmic radio waves- intense flashes of radio emission that last just a few millise ...
DEC 12, 2020
Space & Astronomy
Superhighways in Space Enable Super Fast Travel Between Planets
DEC 12, 2020
Superhighways in Space Enable Super Fast Travel Between Planets
Astronomers from Serbia have found that invisible structures created by gravitational interaction in our Solar System ge ...
MAR 09, 2021
Plants & Animals
Study Highlights Importance of Chinook Salmon to Endangered Orcas
MAR 09, 2021
Study Highlights Importance of Chinook Salmon to Endangered Orcas
Many issues plague the iconic orcas of the Pacific Northwest United States, including declining salmon populations. ...
MAY 29, 2021
Space & Astronomy
First Matter in the Universe Flowed Like Tap Water
MAY 29, 2021
First Matter in the Universe Flowed Like Tap Water
In two separate studies, researchers led by those at the University of Copenhagen and Queen Mary University of London fo ...
JUN 17, 2021
Space & Astronomy
Chinese Astronauts Will Live on New Space Station for 3 Months
JUN 17, 2021
Chinese Astronauts Will Live on New Space Station for 3 Months
Astronauts aboard China’s first manned spacecraft in almost five years have reached the new Tiangong space station ...
JUN 21, 2021
Space & Astronomy
Scientists Detect Signatures of Life on Earth Remotely
JUN 21, 2021
Scientists Detect Signatures of Life on Earth Remotely
An international team led by researchers from the University of Bern in Switzerland and the National Centre of Competenc ...
Loading Comments...