AUG 28, 2017 06:27 PM PDT

Melanoma and the Melanocyte Model

WRITTEN BY: Carmen Leitch

In this video from the Koch Institute at MIT, you can see work that won an Image Award for 2017. The image was generated by Dahlia Perez of the Lees lab, who explains her research. The lab studies how chemical cascades or pathways function in normal biology, and how they go wrong in disease. This picture is a part of an investigation of melanoma in a zebrafish model.

Zebrafish have cells called melanocytes that are pigmented with melanin. These cells are seen in the image in black along with another type of pigmented cell that is yellow. These cell types give zebrafish their coloration. The melanocytes are also the origin of melanoma.

There are two types of genetic mutations associated with melanoma, one of the skin and one of the eye. But treatments for melanoma that impacts the skin don't work for that of the eye. The human mutations were put into the zebrafish genome (and designed to affect the melanocytes only), to observe the impacts. This work can help reveal more about how to treat different types of melanoma.
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
NOV 05, 2018
Videos
NOV 05, 2018
How UV Rays Cause Aging and Skin Cancer
We know that UV rays can do damage to our DNA - but how?...
NOV 11, 2018
Videos
NOV 11, 2018
Is Our Everyday Electronic Devices Making Us Sick?
1-5% of people believe their electronic devices are making them experiences symptoms associated with such as nausea, dizziness, and headaches. These indivi...
NOV 14, 2018
Videos
NOV 14, 2018
Visualizing Embryonic Development in Zebrafish
Zebrafish share genetic features with many other organisms, and they undergo a rapid developmental process in which they can remain transparent....
NOV 26, 2018
Health & Medicine
NOV 26, 2018
Nontuberculous Mycobacterial Infections in Tattoos
Contracting an infection when getting a tattoo is always a major concern. Consumers should be aware of the risk of developing infections with bloodborne pa...
NOV 28, 2018
Videos
NOV 28, 2018
Nanorobots That can Move Through the Eye
Researchers want to create tiny drug delivery systems that can move through biological tissue....
DEC 12, 2018
Videos
DEC 12, 2018
Why Don't We Clone Extinct or Endangered Animals?
While estimates about the number of species that go extinct vary widely, one thing is certain: we can list many animals that have gone extinct....
Loading Comments...