NOV 24, 2018 1:00 PM PST

Gene signature predicting immune therapy

WRITTEN BY: Sharvin Manickam

 

Extracellular matrix (ECM), nature’s microscopic sandwich, had recently made to the limelight, through the efforts of Dr. Daniel De Carvalho, who hailed from Princess Margaret Cancer Centre. Notably, its gene signature is of focus.      

Dr. De Carvalho muses that ECM gene signature associated with response to immune therapy is vital as there is no mature way to predict patients that will respond accordingly well. 

ECM has long since been accepted to be one of the hallmarks of cancer. Out of ten, ECM’s dynamics’ deregulations helps the said cancer progression. The experimental pursuit had identified a novel immune evasion signature. 

Dr. De Carvalho went on to explain that ECM physically barricades the immune system when patients that were supposed to response do not. This then collectively helps to decide who should receive the immune therapy, besides hypothesizing why the patients might not have responded well previously - through the provision of the biomarker. 

Hence the ultimate goal. To find a biomarker that helps clinicians to decide - might the patients requires immunotherapy. Should any patients respond poorly, they will receive a drug that targets ECM, and later responds with conviction towards the immunotherapy.  

Sources: Nature CommunicationUniversity Health NetworkScience Direct

About the Author
  • An aspiring scientist, dreaming for impossible answers, A glad lad gladly searching for it.
You May Also Like
NOV 06, 2020
Space & Astronomy
300 Million Planets in the Milky Way May Be Habitable
NOV 06, 2020
300 Million Planets in the Milky Way May Be Habitable
Researchers have found that there could be at least 300 million habitable worlds in the Milky Way galaxy. This could mea ...
NOV 12, 2020
Chemistry & Physics
Can a Chemical Be Both Nurturing and Destructive?
NOV 12, 2020
Can a Chemical Be Both Nurturing and Destructive?
On August 4, a megascale explosion almost leveled half of Beirut, the capital city of Lebanon. At the center of the negl ...
JAN 13, 2021
Space & Astronomy
Astronomers Identify Another Crucial Aspect for Planets to Support Life
JAN 13, 2021
Astronomers Identify Another Crucial Aspect for Planets to Support Life
For some time now, we have known of the 'Goldilocks zone'- a distance from the sun that leads to planets neither ...
FEB 10, 2021
Space & Astronomy
Do Salt and Melting Ice Cause Landslides on Mars?
FEB 10, 2021
Do Salt and Melting Ice Cause Landslides on Mars?
Recurrent slope lineae (RSL) are dark flows that extend downhill on Mars to form sandy patterns on its surface. Research ...
MAY 13, 2021
Plants & Animals
Brood X Cicadas Are Here - Help Scientists Track Them
MAY 13, 2021
Brood X Cicadas Are Here - Help Scientists Track Them
Download this smartphone app to help document one of North America's natural wonders.
JUN 04, 2021
Plants & Animals
What Elephant Trunks Teach Science about Suction
JUN 04, 2021
What Elephant Trunks Teach Science about Suction
How an elephant picks up a tortilla chip could inspire next-generation suction technology.
Loading Comments...