NOV 24, 2018 1:00 PM PST

Gene signature predicting immune therapy

WRITTEN BY: Sharvin Manickam

 

Extracellular matrix (ECM), nature’s microscopic sandwich, had recently made to the limelight, through the efforts of Dr. Daniel De Carvalho, who hailed from Princess Margaret Cancer Centre. Notably, its gene signature is of focus.      

Dr. De Carvalho muses that ECM gene signature associated with response to immune therapy is vital as there is no mature way to predict patients that will respond accordingly well. 

ECM has long since been accepted to be one of the hallmarks of cancer. Out of ten, ECM’s dynamics’ deregulations helps the said cancer progression. The experimental pursuit had identified a novel immune evasion signature. 

Dr. De Carvalho went on to explain that ECM physically barricades the immune system when patients that were supposed to response do not. This then collectively helps to decide who should receive the immune therapy, besides hypothesizing why the patients might not have responded well previously - through the provision of the biomarker. 

Hence the ultimate goal. To find a biomarker that helps clinicians to decide - might the patients requires immunotherapy. Should any patients respond poorly, they will receive a drug that targets ECM, and later responds with conviction towards the immunotherapy.  

Sources: Nature CommunicationUniversity Health NetworkScience Direct

About the Author
  • An aspiring scientist, dreaming for impossible answers, A glad lad gladly searching for it.
You May Also Like
SEP 11, 2020
Health & Medicine
Trans Fat Regulations Protect Three Billion People Worldwide
SEP 11, 2020
Trans Fat Regulations Protect Three Billion People Worldwide
The World Health Organization (WHO) recently released a progress report on its five-year initiative for the global elimi ...
OCT 14, 2020
Chemistry & Physics
The CRISPR Nobel Win from Different Angles
OCT 14, 2020
The CRISPR Nobel Win from Different Angles
CRISPR-Cas9 was THE buzz word in the world of science after the Nobel Chemistry Prize announcement last week. But depend ...
NOV 06, 2020
Space & Astronomy
300 Million Planets in the Milky Way May Be Habitable
NOV 06, 2020
300 Million Planets in the Milky Way May Be Habitable
Researchers have found that there could be at least 300 million habitable worlds in the Milky Way galaxy. This could mea ...
NOV 27, 2020
Chemistry & Physics
Our Chemistry Connection to Stars and the Cosmo
NOV 27, 2020
Our Chemistry Connection to Stars and the Cosmo
A common entity that connects everything from majestically looking galaxies and nebula to the enormously diversified bio ...
MAR 09, 2021
Plants & Animals
Study Highlights Importance of Chinook Salmon to Endangered Orcas
MAR 09, 2021
Study Highlights Importance of Chinook Salmon to Endangered Orcas
Many issues plague the iconic orcas of the Pacific Northwest United States, including declining salmon populations. ...
MAR 26, 2021
Earth & The Environment
Iconic Bald Eagles are Thriving
MAR 26, 2021
Iconic Bald Eagles are Thriving
Once dangerously on the brink of extinction, bald eagle populations are thriving throughout the lower 48 states of the U ...
Loading Comments...