JAN 21, 2019 11:38 AM PST

Detecting Disease With SHERLOCK

WRITTEN BY: Carmen Leitch

You may have heard about the CRISPR gene-editing tool, which was derived from the bacterial immune system. Used by bacteria in nature to detect and destroy invaders, researchers figured out how to modify this system so it could be applied to cells in the laboratory or in developing animals; it can cut the genome in a place that is specified by the experimenter.

An enzyme that cuts the DNA is essential to this process, along with a piece of RNA that tells the enzyme where to make the cut. While Cas9 is often used as the enzymatic cutter, there are others that can be applied to the CRISPR-Cas system, including Cas13. Scientists at MIT that were involved in developing the CRISPR-Cas9 tool have now created SHERLOCK, which can target RNA with Cas13 instead of DNA (targeted by Cas9). Learn more from the video.

Related: A New Tool in the CRISPR Arsenal

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
MAR 17, 2020
Chemistry & Physics
MAR 17, 2020
Ultra-high-energy Neutrinos to Baffled Particle Physicists: Surprise!
Neutrinos are an aloof member in the sub-atomic particle family: it's electrically neutral, super lightweight (its m ...
APR 19, 2020
Space & Astronomy
APR 19, 2020
Expedition 62 Returns Home From the International Space Station
After spending several months onboard the International Space Station conducting science experiments and risky spacewalk ...
APR 28, 2020
Space & Astronomy
APR 28, 2020
NASA's Swift Telescope Measured the Water Loss of This Interstellar Comet
When the interstellar comet 2l/Borisov made its first appearance in our solar system, astronomers were quick to turn the ...
MAY 03, 2020
Space & Astronomy
MAY 03, 2020
These Contractors Will Develop Lunar Landers for NASA's Artemis Mission
NASA seems to be moving quickly to get the ball rolling for its lunar-centric initiative dubbed Artemis. The program aim ...
MAY 05, 2020
Space & Astronomy
MAY 05, 2020
How Much Do You Know About the Moon?
There are literally dozens upon dozens of natural satellites orbiting the planets in our solar system, but only one of t ...
MAY 14, 2020
Earth & The Environment
MAY 14, 2020
NASA's ICESat-2 Mission Reports Changes in Arctic Ice Thickness
Arctic sea ice is vital to Earth's climate system, and recent decades have seen troubling declines in sea ice due to ...
Loading Comments...