NOV 29, 2015 12:31 PM PST
Use of Cholera Toxin As an Adjuvant
WRITTEN BY: Sarah Hertrich
1 7 934

Vibrio cholerae is a bacterial pathogen that causes a highly contagious diarrheal disease. Once ingested, typically through contaminated food or water, the bacteria are able to colonize the small intestine of the host where they produce cholera toxin (CT). The most common symptom is life threatening watery diarrhea where those affected can lose up 1 liter per hour of water. Natural disasters, such as major floods and earthquakes, as well as poor sanitation are often associated with outbreaks.

In addition to its highly toxic properties, CT has also been found to have high immunogenic properties that have shown potential for beneficial use such as helping induce an immune response when given with vaccines. However; the toxic properties of CT have made its use in humans undesirable. Researchers are now focusing on removing the toxicity from the molecule while maintaining its adjuvant effect.

Sources: Toxins; Davidson College
About the Author
  • I am a postdoctoral researcher with interests in pre-harvest microbial food safety, nonthermal food processing technologies, zoonotic pathogens, and plant-microbe interactions. My current research projects involve the optimization of novel food processing technologies to reduce the number of foodborne pathogens on fresh produce. I am a food geek!
You May Also Like
MAY 08, 2018
Videos
MAY 08, 2018
Virtual Reality Theme Park Opens in China
China's first virtual reality theme park, called Oriental Science Fiction Valley, opened at the end of April 2018. It has a sci-fi focus and offers guests
MAY 15, 2018
Videos
MAY 15, 2018
A Robotic Hand Helps Rehab Patients
When patients have to rehab after surgery, illness or strokes, physical therapy and the accompanying exercises can be a drag. Robotics can help patients re
MAY 16, 2018
Videos
MAY 16, 2018
Bioluminescence Lights Up San Diego Tide
Off the coast of San Diego, microscopic phytoplankton called dinoflagellates are putting on an amazing display of bioluminescence. Scientists at Scripps In
MAY 21, 2018
Videos
MAY 21, 2018
How Skin Allergies Happen
As summer approaches, many of us know to be on the lookout for certain plants that our skin doesn't like. When immune cells that we carry in our epidermis
MAY 22, 2018
Videos
MAY 22, 2018
Could Humankind Terraform Mars or Venus?
Earth might be our natural home in the solar system, but many scientists propose terraforming nearby planets like Mars and Venus such that they can be made
JUN 20, 2018
Videos
JUN 20, 2018
Is it Too Dangerous to Send Humans to Mars?
As it turns out, we have it pretty good on Earth; the planet’s magnetic field keeps us safe from most forms of harmful cosmic radiation that can dama
Loading Comments...