JUL 29, 2020 7:00 AM EDT

What intratumoral Tregs eat makes them strong, but vulnerable: a new metabolic intervention for cancer immunotherapy

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, Department of Fundamental Oncology, University of Lausanne, Associate member, Ludwig Institute for Cancer Research
    Biography
      Ping-Chih Ho is a cancer immunologist with particular research interest in immunometabolism, the tumor microenvironment and viral infection. My ultimate goal is to exploit our findings to better harness our immune system in fight against infection and malignancy. In addition, I also envision to reprogram the tumor microenvironment, reverse immunosuppression and broaden and boost the efficacy of cancer immunotherapy. Ping-Chih Ho grew up in Taiwan and obtained his basic biomedical training, including bachelor degree (Life Science) and master degree (Biochemical Science), at National Taiwan University. He then obtained his PhD in Department of Pharmacology at University of Minnesota. Ping-Chih then did postdoctoral training with Susan Kaech at Yale University, where he demonstrated how cancer cells evade T cell immunosurveillance by depriving infiltrating T cells of glucose, which is consumed in large amounts by malignant cells. In September 2015, he relocated to Switzerland as a tenure-track assistant professor in the Department of Oncology at the University of Lausanne and act as an adjunct scientist at the Ludwig Institute for Cancer Research. Ping-Chih was promoted as a tenured associate professor at the University of Lausanne in August 2019 and promoted to Associate Member at the Ludwig Institute for Cancer Research in January 2020. Png-Chih's research is also supported by University of Lausanne, the European Research Council, the Cancer Research Institute, the Swiss National Science Foundation, the Melanoma Research Alliance, the Swiss Cancer League, Harry J. Lloyd Fund, Anna Fuller Fund, the ISREC foundation. His research is also acknowledged by several international awards, including the EMBO Young Investigator award, MRA-SITC Young Investigator award, CRI CLIP-investigator award, and the Swiss Bridge Award.

    Abstract

    Metabolic reprogramming is critical for governing proper T cell immune responses, including activation, production of effector molecule, migration and differentiation. The metabolic stress T cells could encounter in tumors has emerged as a microenvironmental challenge to tumor-infiltrating T cells. Moreover, the metabolic insufficiency has been observed in tumor-infiltrating T cells associated with declined effector functions. However, it remains unclear why tumor-infiltrating T cells lose metabolic fitness and the detailed impacts of metabolic insufficiency on modulating T cell differentiation. In my talk, I will describe how the tumor microenvironment could influence metabolic fitness and differentiation program in tumor-infiltrating T cells and further provide ideas on boosting T cell anti-tumor responses via metabolic interventions.

     

    Learning Objectives:

    Discover:

    1. Theory and techniques for systems immunology and metabolic control of T cell tolerance and antitumor immunity

    2. How nutrient sensing and signaling in Tregs and the tumor microenvironment could influence metabolic fitness and differentiation program in tumor-infiltrating T cells

    3. Potential approaches for boosting T cell anti-tumor responses via metabolic interventions.


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