Drugs of abuse toxicology testing by immunoassays is widely used clinically, but also known to be inadequate for many clinical indications. In this presentation, the speaker will outline different reasons for which the provider want clinical toxicology testing, and describe a comprehensive solution using both immunoassays and LC tandem mass spectrometry to target individual needs. The speaker will also discuss the performance details of the LC tandem mass spectrometry method. After completing this activity, the learner will be able to describe several clinical needs for toxicology testing. They will also be able to describe a comprehensive solution for clinical toxicology screening, targeted to these individual needs.