JUN 08, 2021 8:00 AM PDT
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Antigen-specific CD4 T cell responses in humans: SARS-CoV-2 and beyond

Sponsored by: Miltenyi Biotec
Speakers
  • Director, Institute of Immunology, Kiel University, Germany
    Biography

      Prof. Scheffold is the Director of the Institute of Immunology at the Universitätsklinikum, Schleswig-Holstein, and the Christian-Albrechts-University, Kiel, Germany. Prior to this, he led the Cellular Immunology Group at the Clinic for Rheumatology and Clinical Immunology of the Charité-Universitätsmedizin, Berlin, and at the German Rheumatism Research Center (DRFZ) Berlin, Germany. He obtained his PhD in Immunology at the University of Cologne in 1997.

    • Global Product Manager, Cell Sorting, Miltenyi Biotec B.V. & Co KG
      Biography
        As a global product manager, Felix is responsible for the development of applications, new protocols, and products for the MACSQuant® Tyto® Cell Sorter from Miltenyi Biotec. Before joining Miltenyi Biotec in 2018, Felix worked as a research associate at the LIMES Institute, University of Bonn, Germany, with a strong focus on Molecular Immunology and Cell Biology. He obtained his PhD in Molecular Biomedicine from the University in Bonn in 2017.

      Abstract

      Date:  June 08, 2021

      Time: 8:00am PDT, 11:00am EDT, 5:00pm CEST

       

      COVID-19 displays high clinical variability, but what determines its severity is unclear. Analysis of antigen-specific T cell responses has contributed to our understanding of the induced immune reaction, and is important in characterizing and potentially predicting the success of vaccination and clinical outcome. Pre-existing T cell memory generated by frequent infections with the related “common cold” Coronavirus (CCCoV) has been hypothesized as a protective mechanism. Prof. Scheffold and his colleagues used a sensitive technology to characterize antigen-reactive T cells directly ex vivo, in combination with closed-system cell sorting on the MACSQuant® Tyto® to enrich and purify antigen-reactive T cells. They were able to characterize SARS-CoV-2‒ and CCCoV-specific T cells from healthy donors and COVID-19 patients using single cell gene expression profiling. Moreover, multiparameter flow cytometry, TCR avidity, and cross-reactivity measurements were used to further deepen the characterization of these cells. The data suggest that pre-existing SARS-CoV-2‒specific memory is not only not protective, but may in fact contribute to the development of severe COVID-19.

       

      Learning Objectives

      • What are the latest insights in the role of SARS-CoV-2‒ and CCCoV-specific T cells in COVID-19 protection and disease progression?
      • Which technologies enable efficient, gentle, and safe isolation of antigen-specific T cells for subsequent deep profiling by, e.g., single-cell genomics analyses?

       

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