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APR 14, 2021 1:30 PM PDT

Automated Solutions for SARS-CoV-2 Variant Identification and Surveillance

Sponsored by: BGI Americas
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Senior Product Manager, Complete Genomics Facility, MGI
    Biography

      Subodh Nimkar is a Senior Product Manager in MGI based in Complete Genomics facility in San Jose CA. His primary responsibilities include management and commercialization of the novel CoolMPS Chemistry for Massively Parallel Sequencing on DNBSEQ platforms. He is also responsible for product management and commercialization of MGIs sequencing solutions in AMERICAS. Over last 20 years he has worked with ABI, Thermo Fisher, Agilent and Streck. He has authored two key patents at ABI and commercialized solutions based on that. He holds a Masters in Chemical Engineering and MBA.

    • Director of Product Management, BGI
      Biography

        Anthony Tong is a Director of Product Management at BGI Americas. He has broad experience in the genomics and diagnostics space, covering oncology and infectious disease testing, companion diagnostics, biomarker and diagnostics development, and non-invasive prenatal testing. He currently leads product marketing for BGI's COVID-19 solution and previously managed the company's NGS solution for the biopharma industry in North America. Anthony received his PhD in Chemical Engineering from Columbia University and MBA from University of California, San Diego. 


      Abstract

      Several SARS-CoV-2 variants are circulating globally. The most prominent variants of concern, including the B.1.1.7, B.1.351 and B1.1.28 lineages, not only carry a constellation of genetic mutations to facilitate virus entry but other mutations found in these variants also might confer increased transmissibility and compromise of RT-PCR assay performance. While next-generation sequencing (NGS) based assays are routinely used to track the new SARS-CoV-2 variants, they require sophisticated NGS lab equipment not accessible by most clinical laboratories, and the assays are expensive with a long turnaround time (TAT).

      This webinar will present a viable alternative to the NGS approach for monitoring these SARS-CoV-2 variants. A rapid, sensitive and cost-effective solution has been developed with the assays run on PCR machines commonly found in most molecular diagnostic labs to detect these variants. These assays can easily be integrated into an Emergency Use Authorization (EUA) workflow that includes high-throughput viral RNA extraction and SARS-CoV-2 detection for testing hundreds or thousands of samples a day. Various automation solutions that enhance the testing capacity and TAT of COVID-19 will also be presented.

      Learning Objectives:

      1. The diversity and detection strategy of SARS-CoV-2 variants 

      2. How integrated workflow is enabling the detection of SARS-CoV-2 and its variants 

      3. The mutation monitoring plan that follows FDA’s new guideline and assures product quality 

      4. The benefits of using the latest advances in lab automaton for COVID-19 testing 


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