OCT 13, 2021 9:00 AM PDT

Comprehensive analysis of next generation biologics using advanced data interpretation software

Sponsored by: SCIEX
C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract
Date:  October 13, 2021
Time: 9:00am (PDT),  12:00pm (EDT)
 
Protein therapeutics is one of the major drug modalities in the biopharma industry. With more and more elucidation of disease pathology, the development of next generation protein therapeutics has become the trend of protein therapeutics development. Unfortunately, these next generation biologics (NGBs) such as fusion proteins exhibit additional levels of complexity beyond regular monoclonal antibody therapeutics. New methods, techniques and efficient data analysis software in liquid chromatography tandem mass spectrometry (LC-MS/MS) hold the key for accelerating the development of NGBs and increasing their availability. Here, a novel LC-MS/MS Q-TOF instrument (ZenoTOF 7600 system, SCIEX) equipped with a patented ion trap will be applied to the acquisition of intact mass and peptide map analysis of complex protein therapeutics. Furthermore, the advanced data processing capabilities of a novel software application (Biologics Explorer software, SCIEX) will be demonstrated.
 
Learning Objectives
  • Discover how protein impurities in intact mass analyses can be easily identified with Biologics Explorer with its powerful visualization tool.
  • Explore how to perform intact mass analysis for heavily glycosylated proteins.
  • Demostrate how to get accurate site-specific N-linked glycan profiling.
  • Explain how to accurately localize O-linked glycosylation.
 
 
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LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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