JUN 10, 2021 9:40 AM PDT

Breakthrough in Spatial Proteomics: Automated High-Resolution LC-MS/MS Tissue Imaging Workflow

  • Kristin Burnum-Johnson

    Senior Scientist and Team Lead, Environmental Molecular Sciences Laboratory
    Pacific Northwest National Laboratory, Richland, WA, USA


Imaging mass spectrometry (IMS) can produce thousands of ion images, providing molecular context to classical histological analysis. New LC-MS proteomics methodologies that have single-cell level sensitivity can now be extended to quantitative proteome mapping using a “voxelation” approach. This has resulted in a depth of proteome coverage and robust quantitation superior to those of existing IMS platforms. The application of this innovative platform to proteome mapping clearly demonstrates the exciting potential of proteome imaging to advance biomedical research.

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