MAY 25, 2021 6:00 AM PDT
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How Busulfan testing improved the management of Bone Marrow Transplant Patients

Sponsored by: Waters Corporation
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Lead Medical Technologist
    Biography

      I earned a Master Degree in Clinical Biochemistry in 1999 at University of Havana. I got Medical Technologist Licenses in Florida in 2003. I worked as a Technical Supervisor in TDM Lab, University of Miami from 2008 until 2017. From 2017 to 2019, I worked in Quality Assurance, Pathology Department at University of Miami. In 2019, I joined to Baptist Hospital of Miami as Lead Medical Technologist of Chemistry Department to implement and validate LC-MSMS procedures as part of the MCI/BMT Project. 


    Abstract

    Date:  May 25, 2021

    Time: 6:00am (PDT),  9:00am (EDT), 2pm (BST), 3pm (CEST)

     

    Therapeutic drug monitoring (TDM) of Busulfan is essential for management of Bone Marrow Transplant (BMT) patients, by optimizing dose, supporting compliance, and minimizing toxicity. Busulfan is a chemotherapeutic agent used as a component in a myeloablative preconditioning regimen before hematological stem cell transplantation. A liquid chromatography-tandem mass spectrometry method for rapid and accurate quantification of Busulfan in plasma was developed and validated in the Department of Chemistry at Baptist Hospital of Miami. The TDM and timely plasma concentration reporting of Busulfan would provide an improvement in the quality-of-care for BMT patients. 

     

    Learning Objectives

    • Identify our purpose to measure Busulfan in BMT patients’ samples.
    • Describe a clinical method to measure Busulfan in plasma by LC-MS/MS.
    • Describe the validation results of the method to measure Busulfan in plasma by LC-MS/MS.

     

     

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