MAR 20, 2014 1:00 PM PDT

Cholinergic modulation of visual perception in rodents

Presented at: Neuroscience
Speaker
  • Full professor Ecole doptomtrie, Universit de Montral, Qubec, Canada
    Biography
      Dr Vaucher obtained her PhD Neurosciences at Universit Paris VI. CNRS UA 641, Paris / Institut Neurologique de Montral, Qubec. She has completed two post-doctoral formations in the field of the involvement of the cholnergic deficit in Alzheimer's disease. The aim of her research group is to determine the role of neurotransmitters in the visual processing, especially the role of neuromodulators such as acetylcholine in modifying the cortical representation of specific stimuli and the cortical plasticity. This project will extend the basic knowledge of how the visual stimuli are integrated by the cortical networks (including learning, memory and attentional processes) and will permit to use pharmacological agents as cognitive and/or sensory enhancers to facilitate sight recovery and cortical plasticity.

    Abstract

    The cholinergic system is a potent neuromodulatory system which plays a critical role in cortical plasticity, attention and learning. The cholinergic activation of the cortex increases the signal-to-noise ratio, cue detection ability and the strength of the thalamocortical afferences relative to cortico-cortical signaling. These changes facilitate the treatment of a novel stimulus.
    We are particularly interested in the role of the cholinergic system in visual processing and cortical plasticity of the visual cortex (V1). Our laboratory uses a large panel of techniques behaviour, neurophysiology, neuroanatomy and optical imaging - to examine this issue from a cellular to an integrated and behavioural level. We have recently demonstrated that acetylcholine (ACh) was released in V1 during a pattern visual activation. The cholinergic deficit impaired the visually-induced neuronal activity in the layer 4 of V1 and the performance of the rat in a visual learning task. Moreover, deletion of different subtypes of muscarinic receptors in KO mice selectively altered the intrinsic organization of V1 suggesting a strong involvement of the muscarinic transmission in the detectability of visual stimuli. The transient coupling of cholinergic and pattern visual stimulation induced a long-term enhancement of the visual evoked potentials mediated by muscarinic, nicotinic and NMDA receptors. This cholinergic-induced long-term modifications of the cortical functioning also improved visual perception. Activation of the cholinergic system paired with visual stimulation over two weeks induced a long-term increase of visual evoked potentials in V1 and of the visual acuity of the rats.
    Our results demonstrate that the pairing of the cholinergic system activation with visual training improved the visual performance of the animals and functional organization of V1. This study opens the possibility of boosting V1 plasticity and facilitating visual recovery.
    Supported by CIHR, NSERC, FRQS Vision Research Network.


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    MAR 16, 2021 10:00 AM PDT
    C.E. CREDITS
    MAR 16, 2021 10:00 AM PDT
    Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    FEB 24, 2021 10:00 AM PST
    C.E. CREDITS
    FEB 24, 2021 10:00 AM PST
    DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    MAR 20, 2014 1:00 PM PDT

    Cholinergic modulation of visual perception in rodents

    Presented at: Neuroscience

    Specialty

    Research And Development

    Earth Science

    University

    Research

    Health

    Geography

    North America67%

    Asia33%

    Registration Source

    Website Visitors100%

    Job Title

    Medical Laboratory Technician100%

    Organization

    Pharmaceutical Company67%

    Manufacturer - Other33%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more