MAY 07, 2018 10:00 AM EDT

Managing CMV Infection and Realizing Operational Efficiencies in your Laboratory

  • Senior Staff, Infectious Diseases Division at Henry Ford Health System, and Clinical Associate Professor of Infectious Diseases, Wayne State University in Michigan
      Dr. John Ernest McKinnon is a senior staff in the Infectious Diseases Division at Henry Ford Health System and a Clinical Associate Professor of Infectious Diseases at Wayne State University in Detroit, Michigan. His research includes work on HIV, HIV viremia, HIV resistance, CMV infection in immunosuppressed patients including the current work on CMV resistance studies the impact of mutations on PCR amplification and detection of CMV viremia. Additional research focuses in the predictors of infectious complications and impact of opportunistic infections such as CMV in immunosuppressed populations, in patients receiving immunosuppressive therapy with autoimmune disorders and hematogenous stem cell transplants. Dr. McKinnon serves a member of the Institutional Review Board, Provider Advisory Council and on other committees at Henry Ford Hospital.
    • Professor & Vice Chair, Laboratory Medicine, and Medical Director of Clinical Laboratories & Molecular Pathology, Medical University of South Carolina
        Dr. Frederick (Rick) S. Nolte is currently Professor and Vice Chair for Laboratory Medicine in the Department of Pathology and Laboratory Medicine, and Medical Director of Clinical Laboratories and Molecular Pathology at the Medical University of South Carolina. He is active in and held positions of responsibility in the American Society for Microbiology, Association for Molecular Pathology, Clinical and Laboratory Standards Institute, Infectious Diseases Society of America, American Society for Clinical Pathology, American Association for Clinical Chemistry, and College of American Pathologists. He has authored numerous book chapters, practice guidelines, and more than 100 peer-reviewed publications in the areas of clinical microbiology and molecular diagnostics.


      BROADCASTING on location at the Clinical Virology Symposium

      Our first presenter, Dr. John McKinnon, will be presenting on:


      Human cytomegalovirus (CMV) infection is prevalent in transplant patients, and is frequently associated with significant morbidity and mortality. In CMV positive recipients of allogeneic human stem cell transplantation, the incidence of viral reactivation can be seen in up to 80% of patients, with up to 30% of these patients ultimately developing clinically significant CMV disease.1 The potential clinical impact of missing CMV viremia cannot be understated. In the first part of this presentation, Dr. John McKinnon will present data from his study comparing two commercial assays for the quantitation of CMV and potential relationship with mutations on UL54.  

      Learning Objectives:

      • Review of the current recommendations for CMV viral load monitoring in patients undergoing hematopoietic stem cell transplantation
      • Clinical study results of comparing two commercial assays for CMV viremia and genotypic resistance testing of samples with CMV viremia.
      • Clinical implications for our site and potential approaches to management of suspected CMV viremia.

      Our second presenter, Dr. Frederick (Rick) Nolte, will be presenting on:


      Consolidation of laboratory testing on a single automated molecular platform can result in many benefits to the laboratory, namely by reducing the number of redundant instruments, streamlining operations, and standardizing testing – all of which may translate into considerable cost savings and improved operational efficiency. In the second part of this presentation, Dr. Rick Nolte presents his experience with consolidating IVDs and LDTs on a versatile molecular platform.

      Learning Objectives:

      • Discuss the key factors to consider in selecting a molecular diagnostic test platform
      • Describe our experience with consolidation of LDTs and IVDs on the Abbott m2000 platform
      • Highlight the operational efficiencies that can be achieved through Lean laboratory design and the use of middleware in molecular diagnostic laboratories


      1 J.E. McKinnon et al. Comparison of Roche and Abbott Cytomegalovirus Quantitative PCR Assays in Allogeneic Hematopoietic Cell Transplant Recipients. Poster presented at IDWeek, October 4-8, 2017, San Diego, CA

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      MAY 07, 2018 10:00 AM EDT

      Managing CMV Infection and Realizing Operational Efficiencies in your Laboratory


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