Pharmacogenomics has emerged as an early use case of precision medicine. Delivering this new clinical data to clinicians in a ready to use format can be challenging. This talk will cover key decision points and components needed for a systemic-wide implementation of pharmacogenomics. NorthShore University HealthSystem’s Personalized Medicine Program will be used as an example to highlight a number of these concepts. This talk should help the attendee begin to formulate a plan for implementation.