DEC 05, 2019 05:00 AM PST

The clinical implications of high sensitive assays for HBsAg

SPONSORED BY: Abbott Diagnostics
Speakers
  • Associate Medical Director, Infectious Diseases - Abbott Diagnostics
    Biography
      Born and living in Roma (Italy). Married, one son and one daughter. Employed at Abbott Diagnostics in several scientific roles since February 1988. Currently, Associate Director Medical & Scientific Affairs, with global responsibility for Infectious Diseases.
      Medical degree ("Sapienza" University of Roma, Italy), Postgraduate specialization in Gastrointestinal Diseases, PhD in Infectious Diseases. Member of Italian and European Associations for the Study of the Liver (AISF, EASL); European Society of Clinical Microbiology and Infectious Diseases (ESCMID); Italian Society of Virology (ISV/SIV); Italian Blood Transfusion Society (SIMTI); European Society of Cardiology (ESC); American Association for Clinical Chemistry (AACC). Adjunct professor ("Sapienza" University of Roma) at postgraduate schools in Clinical Microbiology (years 1994-1999) and Clinical Pathology (1997 and 2001-2007). Seminars on infectious diseases diagnosis at the National Institute of Health (Roma, Italy) in 1996 and 2002-2003. Lectures at >100 CME events or equivalent, Italy and abroad. Author or coauthor of 229 scientific papers, of which 69 on international, peer-reviewed journals. More than 400 posters/oral communications and National or International congresses, most of which on Viral Hepatitis & HIV.
      The most recent research activities in the Infectious Diseases area are: 1. development and validation of an off-label procedure for HIV antibody avidity as a tool for identifying recent infections; 2. clinical usefulness of hepatitis C virus core antigen (HCVAg) in diagnosis and monitoring, including health economic perspectives; 3. qualitative and quantitative serological biomarkers for hepatitis B virus (HBV) infection.

    Abstract:
    DATE:  December 5, 2019
    TIME:   5:00am PST, 8:00am EST
     
    The diagnosis of an active infection by the hepatitis B virus (HBV) relies on testing for the HBV surface antigen (HBsAg). Over the decades the sensitivity of HBsAg assays has increased, and the most recent solutions attain a level of 5 mIU/mL and enable to detect active HBV also at very low level of expression, with HBV-DNA levels <100 mIU/mL. The availability of such assays will help improve the safety of blood screening in settings that do not encompass testing for HBV-DNA and will enable unveiling HBsAg in a substantial share of "occult" or "latent" HBV infections (OBI). Unveiling OBIs has a great clinical relevance in immunocompromised or immunosuppressed patients and in people coinfected by other viruses, such as HCV or HIV. Additionally, since the negativity for HBsAg is a major endpoint for antiviral treatment with nucleosi(t)ide analogues, a higher sensitivity for HBsAg can help with a safer interruption of treatment.
     
    Learning Objectives:
    • Review the natural history of HBV infection and the progress in HBsAg testing
    • Understand the mechanism and clinical implications of HBV reactivation
    • Acknowledge the medical improvements linked to a better sensitivity for HBsAg
     
     
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