SEP 12, 2019 08:00 AM PDT
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Clinical uses of Mass Spectrometry

SPONSORED BY: Agilent
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Laboratory PRISM - University of Lille
    Biography
      Nina Ogrinc's career in mass spectrometry started as a graduate in Analytical Chemistry at the University of Ljubljana, and the Department of Low and Medium energy Physics, Jozef Stefan Institute, Slovenia. In 2015, she finished her PhD developing a new analytical method on a tandem accelerator which allowed dual imaging with MeV Secondary Ion Mass Spectrometry (SIMS) and Particle induced X-Ray emission (PIXE). The method was used for quantitative elemental and molecular imaging of thin sections (from cells to biological tissue sections).
      In 2014, she joined the group of Prof. Ron Heeren (M4I) in Maastricht, Netherlands as a postdoctoral researcher. In her 4 years in this role, she was involved in the Marie Curie BRAINPATH consortium and actively engaged in a variety of projects where she developed and applied new mass spectrometry imaging tools for biomarker discovery (lipids, metabolites, peptides) of neurodegenerative diseases. Her expertise specifically lay in high-resolution imaging with Secondary Ion Mass Spectrometry where she increased the sensitivity of detecting larger molecules, such as peptides, for new sequencing strategies.
      Since October 2018 she is working at laboratory PRISM (University of Lille), under the direction of Prof Michel Salzet and Prof. Isabelle Fournier, on a highly innovative SpiderMass project, an instrument designed for guided surgery and real-time diagnosis in the surgical operating room.
    • DermoCosmetic - Pierre-Fabre Laboratories - Toulouse, France
      Biography
        After a bachelor's degree in cell biology and physiology, Philippe Saudemont graduated from a proteomic master focused on biotechnology and mass spectrometry. He then worked as an engineer for a technology transfer organization (TTO, "SATT-Nord"). During this time, he worked on the development of a SpiderMass© prototype for guided surgery in Pr. Michel Salzet & Pr. Isabelle Fournier PRISM Laboratory (University of Lille, France). This was successfully concluded with the use of the system directly by veterinarians during surgeries and the building of a 96% specificity dog soft tissue sarcoma classification model. Following his engineer position, his interest in instrumentation brought him to begin a PhD under the direction of Pr. I. Fournier. He is currently working on the adaptation and uses of the SpiderMass© system in the field of DermoCosmetic in collaboration with Pierre-Fabre Laboratories (Toulouse, France). His work brings him into the area of human clinical trials for the validation of cosmetic product under development and the study of physiopathological skin conditions.

      Abstract:

      DATE: September 12, 2019
      TIME: 8:00am PDT

      In the upcoming era of personalized medicine, there is a growing need for the development of rapid, sensitive, precise and accurate analysis of tissues in their native environment. By preserving the samples in their original state, without the need of sample preparation, scientists and clinicians can better decipher the underlying biological mechanisms required in clinical applications. For example, the improvement of cancer treatment and prognosis highly relays on the development of novel technologies allowing for rapid molecular diagnosis in an intraoperative context of cancer surgery.


      The development and use of ambient ionization MS (AIMS) techniques has become widespread since they require minimal sample preparation for analysis, contrary to traditional vacuum based MS approaches. In the first instance AIMS were used for tissue profiling and biomarker discovery and in the second, for imaging in combination with histology for morphology-based tissue analysis. The next step is to bring these MS technologies even closer to the patients for in vivo and real-time sampling. This has been achieved by the development of several in vivo probes. Amongst them is the SpiderMass system which has been developed at the PRISM Laboratory (Lille) and successfully applied in several clinical projects. The most recent applications enabled tumor typing and grading of dog ex vivo sarcoma biopsies in the lab and in vivo tissues during surgery in a veterinary surgical theatre.

       

      Learning Objectives:

      • How MS development has advanced in clinical labs and hospitals 
      • How the molecular information obtained by MS can be related to health and disease
      • How the SpiderMass developed in PRISM can help clinicians in their daily routine

       

      Webinars will be available for unlimited on-demand viewing after live event.

       

      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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