AUG 21, 2013 1:00 PM PDT

Codon optimization: new safety concerns for gene therapy and genetic vaccines

C.E. Credits: CE
Speaker

Abstract

Codon-optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. It is used extensively for expressing recombinant protein drugs, gene therapy, and DNA/RNA vaccines. However, it is becoming increasingly clear that codon-optimization can affect protein conformation and function, increase the immunogenicity of recombinant protein drugs, and reduce efficacy. This presentation will analyze the mechanisms and assumptions underlying codon optimization and identify additional hazards associated with this approach, including unique hazards for gene therapy and DNA/RNA vaccine applications.


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AUG 21, 2013 1:00 PM PDT

Codon optimization: new safety concerns for gene therapy and genetic vaccines

C.E. Credits: CE

Specialty

Virology

Earth Science

Antibodies

Immunology

University

Dna Sequencing

Personalized Medicine

Clinical Diagnostics

Immunity

Immunotherapy

Cancer Diagnostics

Flow Cytometry

Bioinformatics

Immuno-Oncology

Research

Geography

Europe67%

Asia33%

Registration Source

Website Visitors100%

Job Title

Student67%

Medical Laboratory Technician33%

Organization

Academic Institution33%

Research Institute33%

Manufacturer - Other33%


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