OCT 05, 2016 10:30 AM PDT

Comparative genetic and transcriptome analyses of Hepatocellular Carcinoma and Endometrioid Endometrial Carcinoma highlight common molecular and biological processes

Speaker
  • Principal Scientist, QIAGEN Bioinformatics
    Biography
      Jean-Noel Billaud, Ph.D. is Principal Scientist at QIAGEN Bioinformatics. He joined Ingenuity Systems (now QIAGEN) in 2008 as staff scientist for in silico research program in oncology and infectious diseases. Jean-Noel Billaud holds a Ph.D. in Blood Cell Biology from Paris VII, and has done his post-doctoral work at the Scripps Research Institute (San Diego, CA).

    Abstract

    Hepatocellular Carcinoma (HCC) and Endometrioid Endometrial Carcinoma (EEC) are two lethal diseases of public health importance worldwide. Understanding the mechanisms of tumor progression in both cancers could be essential for the detection of common biomarkers. Using QIAGEN’s RNA-Sequencing solutions, we were able to highlight key molecular and biological processes that indicate similarities in the tumor progression toward metastasis. This approach may be useful in the context of precision or personalized medicine. Examining the gene expression in tumors from groups of patients with each disease revealed that at a molecular level, early stages of EEC resemble established HBV-positive, HCV-negative, liver cirrhosis positive HCC.
     


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