Hepatocellular Carcinoma (HCC) and Endometrioid Endometrial Carcinoma (EEC) are two lethal diseases of public health importance worldwide. Understanding the mechanisms of tumor progression in both cancers could be essential for the detection of common biomarkers. Using QIAGEN’s RNA-Sequencing solutions, we were able to highlight key molecular and biological processes that indicate similarities in the tumor progression toward metastasis. This approach may be useful in the context of precision or personalized medicine. Examining the gene expression in tumors from groups of patients with each disease revealed that at a molecular level, early stages of EEC resemble established HBV-positive, HCV-negative, liver cirrhosis positive HCC.