MAR 05, 2019 10:00 AM PST
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Comprehensive Capture of Human Neuropathology by Multiplexed Ion Beam Imaging (MIBI)

SPONSORED BY: IONpath
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Assistant Professor, Pathology Stanford University
    Biography
      Dr. Bendall's is an expert in protein biochemistry, mass spectrometry, and stem cell biology, and single cell analysis. His lab creates new methods for single cell proteomics that are applied to human stem cell biology, cancer immunology, and neurodegenerative disease. These include his pioneering work in ICP-MS based flow cytometry (CyToF) for studying the regulation of the human hematopoietic immune system in health and disease as well as leveraging multiplexed ion beam imaging for human neuropathology. His lab continually uses the collection of these tools for correlating single cell pathobiology with clinical outcomes in retrospective studies.

    Abstract:

    DATE: March 5, 2019

    TIME:  10:00am PST

    Single cell analysis, starting with the earliest low parameter fluorescent experiments, helped define the major cell subsets of human cellular systems as we understand them today. Now, a novel combination of single cell analysis and metal isotopes based mass spectrometry (MIBI) offers routine examination of 30+ parameters at the nanometer scale, without interference of spectral overlap characteristic of fluorescent reporters. With this platform, we have reached new levels of organizational understanding in human pathobiology – especially when combined with novel single-cell visualization and analysis methods.  
     Neurodegenerative related disease is estimated to affect five million or more of the ageing American population by 2050. Cognitive care for these individuals is estimated to surpass a trillion dollars a year by middle of next decade.   Accordingly, there is an immediate need for new therapeutic strategies to address this along with identifying unique predictive signatures that correlate with disease mechanism.   
    During this webinar, we will highlight early applications of this new imaging technology to resolve human neurodegenerative disease and cognitive resilience in retrospective studies of human CNS tissues. This work begins to reveal unappreciated layers of human cellular organization and structure in human systems that can be exploited to understand and perturb human pathobiology.

     

    Key learning objectives:

    • Learn the challenges and opportunities for imaging archival CNS tissue
    • Learn the principles of Multiplex Ion Beam Imaging (MIBI)
    • Learn how MIBI is used to capture multi-scale observations in human neuropathology

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