SEP 29, 2020 7:00 AM PDT

Considerations in the Use of Analytical Ultracentrifugation for Characterization of AAV Gene Delivery Vectors

Sponsored by: Beckman Coulter
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Director, Biophysical characterization at Charles River Laboratories.
    Biography

      Christopher Sucato is Associate Director for biophysical characterization at Charles River Laboratories. Prior to joining Charles River, as part of the acquisition of Blue Stream Laboratories, Dr. Sucato led the biophysical group at Blue Stream from 2010 to 2016. Dr. Sucato was a Ruth L. Kirschstein National Research Service Award fellow at the Departments of Biomedical Engineering and Biophysics at Boston University, where he developed nanoparticle-based agents for the early detection of biomarkers in inflammation. Dr. Sucato's research experience includes characterization of protein-protein and protein-nucleic acid interactions by a range of techniques, and the evaluation of kinetic interaction constants. Dr. Sucato holds a Ph.D. (2008) in Chemistry/Biochemistry from the University of Southern California.


    Abstract

    Date:  September 29, 2020

    Time: 7:00am PDT,  10:00am EDT

     

    Analytical Ultracentrifugation (AUC) in the biopharmaceutical industry has traditionally been employed in the analysis of aggregation and higher order structure in protein drug products. More recently, gene delivery vectors have opened new avenues for AUC-based characterization and QC lot release methodologies. We discuss here the parameters of an AUC method which conform to the objectives of an ICH/cGMP validation and suggest gap-bridging strategies to maintain a high-quality AUC platform for use in AAV programs.

     

    Learning Objectives:

    • Understand the AUC parameters used to characterize AAV gene therapy vectors.
    • Learn how AUC can help in characterization of viral vectors for lot release.
    • Learn about strategies and methods used to bring AUC in line with cGMP.

     

    Webinars will be available for unlimited on-demand viewing after live event.

     

    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    FEB 24, 2021 10:00 AM PST
    C.E. CREDITS
    FEB 24, 2021 10:00 AM PST
    DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
    NOV 10, 2020 7:00 AM PST
    C.E. CREDITS
    NOV 10, 2020 7:00 AM PST
    DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
    Loading Comments...
    Show Resources
    Attendees
    • See more