Considerations in the Use of Analytical Ultracentrifugation for Characterization of AAV Gene Delivery Vectors

Date:  September 29, 2020

Time: 7:00am PDT,  10:00am EDT

Analytical Ultracentrifugation (AUC) in the biopharmaceutical industry has traditionally been employed in the analysis of aggregation and higher order structure in protein drug products. More recently, gene delivery vectors have opened new avenues for AUC-based characterization and QC lot release methodologies. We discuss here the parameters of an AUC method which conform to the objectives of an ICH/cGMP validation and suggest gap-bridging strategies to maintain a high-quality AUC platform for use in AAV programs.

Learning Objectives:

• Understand the AUC parameters used to characterize AAV gene therapy vectors.
• Learn how AUC can help in characterization of viral vectors for lot release.
• Learn about strategies and methods used to bring AUC in line with cGMP.

Webinars will be available for unlimited on-demand viewing after live event.

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.