MAY 13, 2020 8:00 AM PDT

Coronavirus Disease 2019 (COVID-19): Role of Serologic Testing in Diagnosis and Assessment of Viral Immunity

  • David M. Engman, MD, PhD

    Chairman Emeritus of Pathology, Cedars Sinai Medical Center - Clinical Professor of Pathology, UCLA - Adjunct Professor of Pathology, Northwestern University

  • Provide education on COVID-19 disease and SARS-CoV-2.
  • Review the types of tests used for the diagnosis of infectious diseases.
  • Discuss approaches to serologic test development.
  • Review the kinetics of the antibody response and the functions of immunoglobulin subclasses in the immune response and analytes for monitoring immunity to a pathogen (SARS-CoV-2)
  • Discuss pros and cons in measuring virus-specific IgG vs IgG+IgM.
  • Discuss the functions of the SARS-CoV-2 proteins commonly employed in serologic assays—Nucleocapsid Protein and Spike Protein.
  • Review the differences and similarities of diagnostic antibodies and neutralizing antibodies.

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