MAY 20, 2020 10:00 AM EDT | APAC MAY 21, 2020 1:00 PM CST

How COVID-19 has Changed an Immuno-oncologist's Life: from Optimizing Daily Practice to the Targeted Treatment of Cytokine Storm

Speaker

Abstract

The spread of severe acute respiratory syndrome coronavirus 2 (SARS CoV2), changed the daily life of medical oncologists. To keep safe both patients and healthy workers is the most important rule. In our daily practice we adopted a specific policy about the conduct of our clinical managements of melanoma patients, in order to minimise the risk of any potential exposure. In addition, immuno-oncologists may have an important role during such pandemic. Indeed, they have an important experience in the management of immuno-related adverse events due to the hyperactivation of immune system as consequence of immunotherapy. Since the acute respiratory distress syndrome by COVID-19 seems to occur from an excess of cytokine production, some drugs used in the management of immune-related side effects could be useful for treating ARDS by COVID-19. In particular, they know the key role played by IL-6 in the pathogenesis of these kind of hyperinflammation syndromes. In Italy we started on 19th of March a phase II study (NCT04317092), which enrolled 330 patients in 24 hours, looking to the ability of tocilizumab to reduce the one-month mortality rate as main study endpoint. Results should be reported very soon. Other drugs active in reducing the cytokine release syndrome are at moment in clinical trial or expanded access program like JAK inhibitors, complement inhibitors, toll like receptor inhibitors and others.


Show Resources
You May Also Like
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
SEP 13, 2022 8:00 AM PDT
SEP 13, 2022 8:00 AM PDT
Date: September 13, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Preparedness against pandemic diseases demands rapid-response vaccine technology and ready-to-use analytical methods...
JUN 29, 2022 8:00 AM PDT
JUN 29, 2022 8:00 AM PDT
Date: June 29, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CEST) As of May 2022, there have been more than 500 million confirmed cases of COVID-19, including numerous variants. Additiona...
Loading Comments...
Show Resources
Attendees