JUL 21, 2017 10:00 AM PDT

WEBINAR: CRISPR/Cas9: Moving from Founder Mice to Phenotyping

Speaker
  • Senior Director, Genetic Engineering, Transgenic Genotyping, and Reproductive Sciences , The Jackson Laboratory
    Biography
      Dr. Grass has been involved in the generation of genetically modified mice for more than 25 years. He received his Ph.D. in Molecular Biology from Columbia University in New York, and was a post doctoral fellow at The Sloan Kettering Institute for Cancer Research, where the focus of his research was molecular immunology. Dr. Grass spent an extensive amount of time at a small biotech company (Xenogen Biosciences, previously known as DNX), where his groups were responsible for genetically modified model generation as well as phenotyping and in vivo compound assessment. Dr. Grass is currently the Senior Director, Genetic Engineering, Transgenic Genotyping, and Reproductive Sciences, with responsibility for the model generation program at the Jackson Laboratory.

    Abstract

    DATE: July 21, 2017
    TIME: 10:00am PT, 1:00pm ET

    CRISPR/Cas9 techniques are quickly growing in popularity for the generation of new mouse models for research. Though the approach is relatively simple, many researchers struggle with understanding the complexities associated with the diverse alleles that can be generated, how to deal with mosaicism, and how to move from a single founder mouse to larger cohorts for phenotype characterization.

    Learning Objectives:

    • Understanding the molecular mechanisms that drive the array of possible mutations that can result from a single Cas9/sgRNA targeting strategy
    • A summary of various common targeting strategies to generate indel, knockout, and knockin mutations using CRISPR/Cas9
    • Selection of founder mice and breeding strategies for mitigating mosaicism in founder mice
    • Breeding strategies to establish a colony and generate cohorts for experimentation

    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    APR 21, 2021 5:00 PM CEST
    APR 21, 2021 5:00 PM CEST
    Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    DEC 16, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 16, 2020 8:00 AM PST
    Date: December 16, 2020 Time: 8:00am (PST), 11:00am (EST) Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better under...
    JUL 21, 2017 10:00 AM PDT

    WEBINAR: CRISPR/Cas9: Moving from Founder Mice to Phenotyping


    Specialty

    Molecular Biology

    Cancer Research

    Genetics

    Biotechnology

    Cell Biology

    Molecular Diagnostics

    Immunology

    Animal Models

    Clinical Diagnostics

    Cancer Therapeutics

    Cancer Diagnostics

    Lab Animals

    Gene Expression

    Cell Culture

    Biochemistry

    Geography

    North America56%

    Europe27%

    Asia8%

    South America5%

    Oceania1%

    Africa1%

    Registration Source

    Website Visitors100%

    Job Title

    Student16%

    Research Scientist16%

    Executive12%

    Educator/Faculty11%

    Scientist9%

    Facility/Department Manager8%

    Post Doc7%

    Veterinarian4%

    Medical Laboratory Technician4%

    Clinical Laboratory Scientist4%

    Medical Doctor/Specialist4%

    Lab Management3%

    Marketing/Sales1%

    Biologist1%

    Organization

    Academic Institution14%

    Research Institute7%

    Biotech Company5%

    Clinical Laboratory4%

    Pharmaceutical Company4%

    Hospital3%

    Government3%

    Ambulatory Care3%

    Medical School3%

    Consultant1%

    Non-Profit Organization1%

    Media1%

    Industrial Company1%

    Life Science Company1%

    Other4%


    Show Resources
    Loading Comments...
    Show Resources