Decoding the Tumor Microenvironment with Paletrra™: Revolutionizing Biomarker Discovery in Clinical Trials

Advances in tissue-based technology in the past few years have created unprecedented opportunities to identify biomarkers of disease processes, especially within oncology by using multi-omics technologies and a wealth of datasets to derive valid and useful signatures of disease. Importantly the use of spatial biology (both RNA and protein) has become a powerful tool for characterizing and phenotyping cells within the tumor microenvironment. Herein, we demonstrate the capabilities of a unique end to end Paletrra™ solution which can be used to generate whole-tissue data for enhanced histological context, and a truly unbiased spatial analysis highlighted within NSCLC. Our comprehensive spatial workflow offers the unique advantage of preserving the architectural features of the tumor, while revealing the spatial relationships between tumor cells and immune cells. This webinar will focus on the characterization of specific cell phenotypes defined by co- localization of multiple proteins and RNA markers that may help in predicting clinical responses and mechanisms of resistance to therapy.

 

 

Learning Objectives