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June 29, 2021 10:40 AM CDT

Development of a Microsatellite Instability Assay Utilizing Novel Long Repeats

C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract

Dr. Samantha Lewis will discuss the value of MSI as a biomarker and techniques to measure microsatellite instability. She will then describe the development of a new PCR assay to detect MSI in solid tumors utilizing a new 8-marker panel that includes both gold standard markers and novel long mononucleotide repeats for a research-based approach to maximize sensitivity. Dr. Lewis will demonstrate the utility of this novel panel by showcasing studies using difficult and degraded samples (ccfDNA and FFPE).

Learning Objectives:

  • Demonstrate how mismatch repair deficiency causes microsatellite instability
  • Recognize techniques to measure microsatellite instability
  • Discuss why long mononucleotide markers may offer a different perspective on MSI

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