APR 10, 2019 12:00 PM PDT

Digital Biosensors and the Internet of Biology

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • CTO, Cardea
    Biography
      Brett's passion is taking nanoelectronic technology out of the theoretical realm to create practical products. His scientific vision led to him founding and serving as CTO of Cardea, a company building the access ports for the Internet of Biology via graphene biosensors. Brett is one of the few people in the world with the combined expertise in biology and nanotechnology needed to develop graphene as a viable bio-electronic device. He was a lead researcher on landmark field effect biosensing papers in Science, Nature Nanotechnology, Scientific Reports, and Nature Biotechnology. His early work established coupling of biochemical systems to carbon nanotubes, for which he won the Nottingham Prize from the Physical Electronics Conference. Dr. Goldsmith earned his PhD in Chemical and Material Physics at UCI, had a postdoc fellowship at University of Pennsylvania, helped develop research programs for ONR and DARPA, and has led the technical team for the world's leading nanotechnology company.

    Abstract

    The prevailing philosophy in biological testing has been to focus on simple tests with easy to interpret information such as ELISA or lateral flow assays. At the same time, there has been a decades long understanding in device physics and nanotechnology that electrical approaches have the potential to drastically improve the quality, speed, and cost of biological testing provided that computational resources are available to analyze the resulting complex data. This concept can be conceived of as “the internet of biology” in the same way miniaturized electronic sensors have enabled “the internet of things.” It is well established in the nanotechnology literature that techniques such as field effect biosensing are capable of rapid and flexible biological testing. Access to this technology opens the door for rapid deployment of nanoelectronic sensors outside the research space. The low power and reagent usage of these biosensors enables biotech engineers to gain immediate control over precise biological and environmental data.

    Learning Objectives: 

    1. Understand how commercialization and general availability of nanoelectronics is changing the cost, speed, and location of biological testing.
    2. Understand the current state of availability and usability of digital biosensors in research and clinical environments.


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