NOV 28, 2018 7:00 AM CET

Discover how single-cell RNA sequencing provides deeper insights into lung cancer biology

Sponsored by: Illumina, 10x Genomics, Inc.
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Assistant Professor, Faculty of Medicine, KU Leuven
    Biography
      My doctoral research was performed at the Center for Human Genetics (KULeuven) under the guidance of Prof. K Devriendt, where we detected cryptic chromosomal aberrations as a novel cause for idiopathic congenital heart defects using arrayCGH. Our studies also identified a new genetic syndrome (16p13.3 duplication syndrome) and a new gene (TAB2) responsible for cardiac defects. Next, I moved to the Babraham Institute in Cambridge (UK), where I worked with Profs. HL Roderick and W Reik to study the epigenetic causes of cardiac hypertrophy, aiming to understand how pathologically hypertrophied hearts re-express their fetal gene programme. We discovered that certain histone methyltransferases normally repress expression of the fetal gene programme in the adult cardiomyocyte, but that these enzymes are downregulated by a micro-RNA upon pressure overload of the heart. I subsequently worked at the VIB Center for Cancer Biology with Prof. D Lambrechts, where we discovered how hypoxia causes DNA methylation changes in tumors, and where we also catalogued the impact of the tumour microenvironment on stromal cells. I currently head the Laboratory for Functional Epigenetics, where we investigate the role of the epigenome on cellular heterogeneity in development and disease.
    • Regional Marketing Manager, EMEA 10x Genomics
      Biography
        Annika Branting works as a regional marketing manager in Europe, Middle East and Africa at 10x Genomics. In this role, she is responsible for identifying and driving marketing projects related to the single cell markets. Her prior roles at 10x Genomics span strategic marketing and support. Annika has a background in biotechnology and engineering with a MSc from the Royal Institute of Technology (KTH) in Stockholm. In her thesis work Annika spent a year as a visiting researcher at the Stanford Genome Technology Center in Palo Alto, California working on functionalized nano-pipettes as biosensors under professor Nader Pourmand.
      • Segment Marketing Manager, Cell Biology, Illumina
        Biography
          Pawel Zajac is the senior cell and molecular biology marketing manager in Europe, Middle East and Africa at Illumina. In this role, he is responsible for developing and executing the marketing plan for this segment. His prior roles at Illumina span several functions in sales and marketing. Pawel has a PhD from the Royal Institute of Technology (KTH) in Stockholm and worked as a PostDoc at the Karolinska Institute in Stockholm. His research focused on method development in single-cell RNA sequencing and multiplex amplification. Pawel is the author of >10 peer-reviewed articles in journals including Nature Methods and Genome Biology.

        Abstract

        DATE: November 28, 2018
        TIME: 7:00AM PST, 4:00PM CET

        Single-cell genomics enables a deep dive into the mechanisms responsible for health and disease, in areas from cancer biology to neurobiology. This webinar will show how single-cell RNA sequencing enabled the creation of a lung tumor microenvironment catalog with more than 50,000 individual cells, offering novel insights into this complex ecosystem. Presented by Dr. Bernard Thienpont from VIB in Leuven, Belgium.

        Learning Objectives:

        • Learn how single-cell sequencing with 10x Genomics and Illumina can enable new scientific discoveries
        • Learn how single-cell gene expression helped to expand our view of lung tumor microenvironment heterogeneity

         

        Annika will discuss: Transform your understanding of genomics, transcriptomics, and epigenomics—10x Technology and Applications

        Whether you want to dissect cell-type differences, investigate the adaptive immune system, or look at tumor heterogeneity on a single cell level, the Chromium System from 10x Genomics is the answer. In this brief presentation I will describe how to characterize and profile hundreds to millions of single cells, combine immune profiling with gene expression data for the same single cell and how to investigate cancer pathogenesis through single cell tumor sub-clones. Further more, the most impending product launches from 10x such as Single Cell ATAC solution and Single Cell Feature Barcode Solution will be briefly discussed. Learn how to enhance your biological discoveries with high-throughput single cell products from 10x Genomics.

        Pawel will discuss: Exploring biological systems at single-cell resolution with Illumina sequencing

        Single-cell sequencing is a collection of methods to examine the genome, transcriptome or epigenome of individual cells. In contrast to studies on bulk material, giving an average across the sample, masking the contributions of individual cells, single-cell analysis provides a high-resolution view of cell types and cell-to-cell variability. Technological advances in the single-cell field over the last couple of years are fuelling a revolution in biology research leading to a deeper understanding of mechanisms in health and disease, in areas spanning cancer biology to immunology, developmental biology to neurobiology. Please join us at this webinar to learn more about the latest news and how Illumina helps to deliver on the promise of single-cell biology.

         

        Sponsored by:

        Illumina - Illumina is transforming human health as the global leader in sequencing and array-based technologies. Illumina’s flexible and scalable sequencing systems support and enable a wide range of single-cell sequencing applications, from low-throughput deep interrogation of rare cell populations to high-throughput profiling of tissues. For more information, please visit www.illumina.com.

         

        10x Genomics, Inc - 10x Genomics, Inc. is building tools for scientific discovery that reveal and address the true complexities of biology and disease. Through a combination of novel microfluidics, chemistry and bioinformatics, our award-winning Chromium System is enabling researchers around the world to more fully understand the fundamentals of biology at unprecedented resolution and scale. Learn more at www.10xGenomics.com.


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