Associate Professor, Cedars-Sinai Medical Center and University California, Los Angeles (UCLA), Assistant Professor, Harvard Medical SchoolBiography
Dr. Dolores Di Vizio is a pathologist and a molecular and cell biologist trained at Albert Einstein College of Medicine, and Harvard Medical School. Dr. Di Vizio is in the faculty at Harvard University since 2007, and holds an academic appointment as associate professor at Cedars-Sinai Medical Center, and UCLA, Los Angeles. Dr. Di Vizio has been studying the molecular mechanisms of progression to advanced disease in human tumors, with particular emphasis on prostate cancer, for over a decade. She discovered that fast migrating and metastatic amoeboid cancer cells release very large extracellular vesicles into the extracellular space. Her group has demonstrated that these vesicles, known as large oncosomes, contain a distinct cargo and play specific function in cancer progression. Ongoing studies in her lab use large-scale approaches, including next generation sequencing, to characterize the molecular profile of large oncosomes and other extracellular vesicles, with the ultimate goal to identify cancer markers in biological fluids. Another focus in the lab is the study of the biological and functional diversity of various populations of extracellular vesicles. Dr. Di Vizio is an executive board member of the International Society of Extracellular Vesicles, and an associate editor for the Journal of Extracellular Vesicles.