MENU
DEC 08, 2015 8:00 AM PST

WEBINAR: Diversity of Cancer-Derived Extracellular Vesicles

Speaker
  • Associate Professor, Cedars-Sinai Medical Center and University California, Los Angeles (UCLA), Assistant Professor, Harvard Medical School
    BIOGRAPHY

Abstract
Cancer-derived extracellular vesicles (EVs) play an important role in cancer progression and metastasis. They can be identified in biological fluids thus providing appealing candidates for novel circulating biomarkers. Studies designed to achieve a deeper understanding of the extent to which EVs propagate oncogenic signals and can be interrogated in clinically relevant settings are increasing. EVs are highly heterogeneous in size, function, biogenesis and mechanisms of communication with target cells. A greater molecular and functional characterization of the EV types that can be released from a given cancer cell will improve our knowledge of the mechanisms underlying cancer progression. Focus of this webinar is a novel EV population referred to as large oncosomes, which originate from the shedding of non-apoptotic membrane blebbing. This biological phenomenon is typical of amoeboid tumor cells with keen migratory abilities and high metastatic propensity. Recent studies demonstrate that large oncosomes are molecular and functional entities that can be distinguished from exosomes and possibly from other EV classes. Further studies on the functional role of large oncosomes and other EVs in specific steps of cancer formation and progression will expand our understanding of the diversity of paracrine signaling mechanisms in malignant growth and metastasis.

Learning Objectives:
  • Understand importance of the role cancer-derived extracellular vesicles (EVs) play in cancer progression and metastasis
  • Understand the role of novel EV population referred to as large oncosomes
  • Understand a novel extracellular vesicle (EV) population referred to as large oncosomes, which originate from the shedding of non-apoptotic membrane blebbing
  • Understand recent studies that demonstrate that large oncosomes are molecular and functional entities that can be distinguished from exosomes and possibly from other EV classes

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUL 15, 2021 8:00 AM PDT
C.E. CREDITS
JUL 15, 2021 8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
MAY 18, 2021 7:00 AM PDT
MAY 18, 2021 7:00 AM PDT
Date: May 18, 2021 Time: 7:00am PDT, 10:00am EDT Proteins encoded by mutant genes in cancers can be processed and presented on tumor cell surface by human leukocyte antigen (HLA) molecules,...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
NOV 17, 2021 8:00 AM PST
C.E. CREDITS
NOV 17, 2021 8:00 AM PST
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
Loading Comments...
Show Resources