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APR 22, 2021 9:00 AM PDT
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Panel Presentation: DPYD Testing: Pharmacogenomics in a Clinical Setting

C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Registered Clinical Scientist, North West Genomic Laboratory Hub (Liverpool) Manchester Centre for Genomic Medicine Liverpool Women's Hospital
    Biography

      Holly Ellis completed her undergraduate degree in Biological Sciences at Oxford University and then went on to complete an MSc in Medical Genetics at Chester University. She gained another MSc in Clinical Sciences (Genomics) as part of the NHS Scientist Training Programme and she now work as a HCPC Registered Clinical Scientist in Genomics at North West Genomic Laboratory Hub (Liverpool). Holly has developed her own YouTube channel and social media platforms as "The Scouse Scientist" to inspire the next generation of scientists and raise awareness of the importance of genomics in the NHS.

    • Clinical Scientist, Genomics, North West Genomic Laboratory Hub (Liverpool)
      Biography

        Dr. Hannah Stevens completed an undergraduate degree in pharmacology, a Master of Research in physiology and a Doctor of Philosophy in molecular and cellular biology at the University of Liverpool. Hannah then worked at the Universities of Edinburgh and Glasgow as a post-doctoral research associate. She now works as pre-registrant clinical scientist in genomics at North West Genomic Laboratory Hub (Liverpool).


      Abstract

      5-Fluorouracil (5-FU) and capecitabine are fluoropyrimidine chemotherapies that are used to treat a range of solid tumours including breast, pancreatic, stomach and colorectal. Metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD), a rate-limiting enzyme encoded by the DPYD gene. Several variants within DPYD are known to cause reduced or abolished DPD activity. Patients harbouring one of these variants are at an increased risk of severe or fatal fluoropyrimidine toxicity. DPD deficiency screening using the YourGene DPYD kit has been implemented in order to identify those patients at increased risk of toxicity and reduce the likelihood of adverse drug reactions.

      Learning Objectives:

      1. To understand the importance of DPYD testing prior to treatment with fluoropyrimidine chemotherapies

      2. To understand how the DPYD testing service has been implemented for use in routine clinical practice


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