NOV 20, 2020 8:00 AM PST

Efficiency to Confidence with High Resolution Accurate Mass Spectrometers: Analyzing IGF-1

Speaker
  • Clinical Development Associate, Mayo Clinic - Clinical Mass Spectrometry Lab and Clinical Forensic and Toxicology Lab
    BIOGRAPHY

Abstract

DATE: November 20, 2020

TIME:   8am PDT, 11am EDT

 

Analysis of Insulin-like growth factor-1 (IGF-1) with high-resolution accurate-mass (HRAM) mass spectrometry  offers significant advantages and allows for identification of single amino acid variants; In contrast, both normal and deleterious sequence variants might be missed by immunoassays or non-HRAM-MS methods. This webinar will highlight a robust and reliable method that was developed to identify IGF-1 variants and distinguish them by a center of mass (COM) calculation, followed by various tandem-MS activation techniques (HCD, ETD, ETciD, EThcD, UVPD) using Thermo Scientific™ Orbitrap™-based mass spectrometry systems.

 

For General Lab Use Only - Not For Diagnostic Procedures.

 

Learning Objectives:

  1. How to use mass spectrometry to detect single amino acid differences in IGF-1 variants.
  2. How to perform qualitative and quantitative analyses of other peptides/proteins in clinical research settings that might lend itself to the characterization of other protein variations.
  3. Demonstrate the power of high resolution to detect protein and peptide analytes in complex biological matrices.

 

 

Webinars will be available for unlimited on-demand viewing after live event.

 

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
OCT 12, 2021 9:00 AM PDT
C.E. CREDITS
OCT 12, 2021 9:00 AM PDT
Date: October 12, 2021 Time: 9:00am (PDT), 12:00pm (EDT) SCIEX’s next-generation Biologics Explorer software is an innovative platform for the comprehensive and deep characterization o...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
OCT 27, 2021 6:00 AM PDT
C.E. CREDITS
OCT 27, 2021 6:00 AM PDT
Date: October 27, 2021 Time: 6:00 AM PDT, 9:00 AM EDT Etanercept is a recombinant Fc fusion protein therapeutic that has a complex distribution of post-translation modifications (PTM), such...
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
Loading Comments...
Show Resources