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Epigenetic Aging Studies in Mammals

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • David Geffen School of Medicine, University of California, Los Angeles
    Biography

      Dr Horvath's research lies at the intersection of aging research, epidemiology, chronic diseases, epigenetics, genetics, and systems biology. He works on all aspects of biomarker development with a particular focus on genomic biomarkers of aging. He developed a highly accurate multi-tissue biomarker of aging known as the epigenetic clock. Dr Horvath developed systems biologic approaches such as weighted gene co-expression network analysis which lend themselves for integrating gene genomic data sets. These methods have been used for a broad spectrum of age related diseases including neurodegenerative diseases, cancer, cardiovascular disease. Dr. Horvath received a Ph.D. in Mathematics from the University of North Carolina, Chapel Hill in 1995 and a Doctorate of Science in Biostatistics from the Harvard School of Public Health in 2000.


    Abstract

    In mammals, DNA methylation is an epigenetic mark that regulates gene expression by serving as a maintainable mark whose absence marks promoters and enhancers. Recent epidemiological studies demonstrate that DNA methylation levels are associated with aspects of biological aging in humans. We present universal mammalian epigenetic clocks that lend themselves for measuring age across mammalian species. We demonstrate that DNA methylation levels are strongly associated with maximum lifespan. These epigenetic clocks are expected to be useful for in vitro studies, animals models, and ultimately human clinical trials.

    Learning Objectives:

    1. Define the concept of an epigenetic clock

    2. Review evidence that epigenetic clocks are indicators of epigenetic age in mammals

    3. Explain what is meant by universal mammalian clock


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